Common neurotransmitter systems studied in PET imaging and radioligands used for each component or pathway involved
| Neurotransmitter System | Component/Pathway Involved | Radioligands Used |
|---|---|---|
| Serotonin | Synthesis | α-[11C]MTrp |
| Transport | [11C]McNeil 5652 | |
| [11C]DASB | ||
| Type 1A receptor | [11C]WAY-100635 | |
| [18F]FCWAY | ||
| [18F]MPPF | ||
| Type 1B receptor | [11C]P943 | |
| Type 2 receptor | [18F]setoperone | |
| [18F]altanserin | ||
| [11C]MDL 100907 | ||
| [18F]FESP | ||
| Dopamine | Synthesis | [18F]fluoro-L-DOPA |
| D1 receptor | [11C]SCH 23,390 | |
| [11C]NNC 112 | ||
| D2/3 receptor | [11C]raclopride | |
| [11C]FLB 457 | ||
| Transporter | [11C]RTI-32 | |
| [11C]CFT | ||
| Monoamine oxidase | Monoamine oxidase type A | [11C]harmine |
| Non-monoaminergic mechanisms | Muscarinic type 2 receptor | [18F]FP-TZTP |
| Nicotinic receptor | [18F]FA-85380 | |
| GABA type A receptor | [11C]flumazenil | |
| Phosphodiesterase type 4 | [11C]-(R)-rolipram | |
| Amyloid and τ proteins | [18F]DDNP | |
| p-glycoprotein | [11C]verapamil | |
| Histamine H1 receptor | [11C]doxepin |