Table 1:

Metaregression analyses and diagnostic performance of ¹⁸F-FDG-PET in subgroups of brain tumors

Analysis	No. of Studies (pts)	I² of Metaregression (95% CI, P Value)	Independent Estimates (95% CI)		LR (95% CI)
Analysis	No. of Studies (pts)	I² of Metaregression (95% CI, P Value)	Sensitivity	Specificity	LR+	LR−
Design
Retrospective	9 (333)	0.00 (0–100, .86)	0.71 (0.58–0.81)	0.73 (0.57–0.85)	2.63 (1.68–4.13)	0.40 (0.29–0.55)
Prospective	15 (524)		0.71 (0.60–0.79)	0.80 (0.66–0.89)	3.45 (1.96–6.07)	0.37 (0.26–0.52)
PET or PET/CT
PET	17 (511)	0.00 (0–100, .38)	0.74 (0.64–0.81)	0.74 (0.60–0.84)	2.82 (1.74–4.55)	0.36 (0.25–0.51)
PET/CT	7 (346)		0.65 (0.50–0.78)	0.84 (0.68–0.92)	3.97 (2.09–7.54)	0.42 (0.29–0.59)
PET measurement
Qualitative	19 (757)	57.87 (4.96–100, .09)	0.69 (0.60–0.76)	0.79 (0.67–0.87)	3.24 (2.00–5.24)	0.40 (0.30–0.52)
Quantitative	4 (85)		0.86 (0.71–0.94)	0.67 (0.43–0.84)	2.59 (1.40–4.81)	0.21 (0.09–0.45)
Malignant grade
Low	14 (330)^{^a}	0.00 (0–100, .46)	0.60 (0.35–0.81)	0.79 (0.64–0.89)	2.87 (1.52–5.41)	0.50 (0.27–0.92)
High	17 (473)^{^a}		0.74 (0.68–0.80)	0.78 (0.65–0.87)	3.35 (2.09–5.38)	0.33 (0.26–0.42)
NS	7 (192)		0.70 (0.50–0.84)	0.70 (0.54–0.82)	2.33 (1.47–3.67)	0.44 (0.26–0.74)
Disease status
SPBT	3 (127)^{^b}	77.72 (51.54–100, .01)	0.43 (0.28–0.59)	0.74 (0.49–0.90)	1.67 (0.59–4.76)	0.77 (0.48–1.24)
SRBT	20 (643)^{^b}		0.75 (0.67–0.81)	0.79 (0.66–0.88)	3.51 (2.17–5.66)	0.32 (0.25–0.41)
Histology
Glioma	17 (609)^{^c,^d}	0.00 (0–100, .47)	0.75 (0.64–0.83)	0.78 (0.64–0.87)	3.36 (2.02–5.59)	0.33 (0.23–0.47)
Nonglioma or NS	8 (250)^{^c}		0.64 (0.52–0.75)	0.75 (0.63–0.84)	2.58 (1.69–3.94)	0.48 (0.35–0.65)

Note:—NS indicates not separable; pts, patients.
↵a Patients with nonneoplastic lesions in 14 studies^{2,6⇓–8,11,12,15,16,18,19,21,23⇓–25} were used for both low- and high-grade subgroups.
↵b Patients with nonneoplastic lesions in 2 studies^8,25 were used for both SPBT and SRBT subgroups.
↵c Five patients with nonneoplastic lesions from Hong et al 2011¹⁶ were used for both glioma and nonglioma subgroups.
↵d One patient with lymphoma in Pauleit et al 2009⁸ and 2 patients with esthesioblastoma and renal cell metastasis in Kahn et al 1994¹² were excluded from subgroup analysis.