Table 5:

Linear regression analysis including diffusion tensor imaging measures, T2 lesion burden, white matter, and cortical volumes in progressive MS

	T1-LV	T2-LV	NWMV	NCV
FA, Total SDGM	−0.152	−0.091	0.005	−0.179
β, P value	.361	.581	.978	.237
Caudate	0.103	0.160	0.377^*	−0.352^*
β, P value	.551	.327	.008^*	.014^*
Thalamus	0.029	0.026	0.053	−0.089
β, P value	.883	.888	.756	.582
Hippocampus	−0.363^*	−0.396^*	−0.002	0.211
β, P value	.011^*	.003^*	.984	.131
MD, Total SDGM	0.289^*	0.449^*	−0.551^*	−0.009
β, P value	.038^*	<.001^*	<.001^*	.964
Caudate	0.223	0.335^*	−0.543^*	0.065
β, P value	.133	.016^*	<.001^*	.672
Thalamus	0.198	0.346^*	−0.387^*	−0.087
β, P value	.174	.010^*	.003^*	.559
Hippocampus	0.404^*	0.569^*	−0.529^*	−0.096
β, P value	.006^*	<.001^*	<.001^*	.553
AD, Total SDGM	0.268^*	0.434^*	−0.546^*	−0.028
β, P value	.050^*	<.001^*	<.001^*	.866
Caudate	0.240	0.366^*	−0.523^*	0.033
β, P value	.097	.008^*	<.001^*	.850
Thalamus	0.214	0.374^*	−0.403^*	−0.109
β, P value	.128	.006^*	.001^*	.464
Hippocampus	0.342^*	0.516^*	−0.566^*	−0.051
β, P value	.023^*	<.001^*	<.001^*	.765
RD, Total SDGM	0.30^*	0.455^*	−0.549^*	0.003
β, P value	.036^*	<.001^*	<.001^*	.985
Caudate	0.213	0.317^*	−0.539^*	0.082
β, P value	.158	.025^*	<.001^*	.592
Thalamus	0.187	0.328^*	−0.375^*	−0.076
β, P value	.208	.017^*	.003^*	.611
Hippocampus	0.426^*	0.582^*	−0.496^*	−0.117
β, P value	<.001^*	<.001^*	<.001^*	.469

Note:—NCV indicates normalized cortical volume; NWMV, normalized white matter volume; T1-LV, T1 lesion volume; T2-LV, T2 lesion volume.
Regression analysis was adjusted for the effects of age, sex, disability level, and disease duration. All P values were corrected for multiple comparisons using Benjamini-Hochberg correction.
↵* indicates significant P values (P < .05) after correction.