Non-familial healthy control subjects and the healthy relatives of patients with multiple sclerosis fulfilling Okuda criteria for RIS or fulfilling modified Okuda criteria for RIS in which the dissemination in space on MRI was evaluated by use of Swanton criteria (RIS-Swanton)
| Non-Familial HCs (n = 82) | Healthy Relatives of Patients with MS (n = 68) | P Value | |
|---|---|---|---|
| RIS-Okuda criteria13 | |||
| Non-RIS | 80 | 66 | .849 |
| RIS | 2 | 2 | |
| Subject 1 | >9 WM SA: 5 JC, 3 PVL, 13 DWM | >9 WM SA: 5 JC, 3 PVL, 13 DWM | |
| Subject 2 | >9 WM SA: 1 JC, 8 PVL, 11 DWM | >9 WM SA: 1 JC, 8 PVL, 11 DWM | |
| Total | 82 | 68 | |
| Modified Okuda criteria (RIS-Swanton13,17) | |||
| Non-RIS | 79 | 61 | .105 |
| RIS | 3 | 7 | |
| Subject 1 | >9 WM SA: 2 JC, 5 PVL, 9 DWM | >9 WM SA: 5 JC, 3 PVL, 13 DWM | |
| Subject 2 | >9 WM SA: 1 JC, 15 PVL, 18 DWM | >9 WM SA: 1 JC, 8 PVL, 11 DWM | |
| Subject 3 | >9 WM SA: 1 JC, 1 PVL, 11 DWM | >9 WM SA: 2 JC, 1 PVL, 7 DWM | |
| Subject 4 | >9 WM SA: 1 JC, 1 PVL, 24 DWM | ||
| Subject 5 | >9 WM SA: 1 JC, 1 PVL, 7 DWM | ||
| Subject 6 | >9 WM SA: 1 JC, 1 PVL, 8 DWM | ||
| Subject 7 | 2 JC, 2 PVL 3 DWM | ||
| Total | 82 | 68 |
Note:—SA indicates signal abnormality; JC, juxtacortical; PVL, periventricular; DWM, deep white matter.
Differences between the groups were compared by means of the χ2 test. The regional localization data for subjects fulfilling RIS criteria are presented on individual subject level.