Outcomes of multivariate logistic regression analyses for NAWM rR after controlling for potential confounders
| Cognitive Test | Odds Ratio (5–95% CI) | P Value |
|---|---|---|
| SDMT | 0.177 (0.040–0.785) | .023 |
| COWAT | 0.662 (0.002–2.226) | .130 |
| PASAT 1.6 | 0.053 (0.003–0.961) | .047 |
Note:—SDMT indicates Symbol Digit Modalities Test; COWAT, Controlled Word Association Test; PASAT, Paced Auditory Serial Addition Test.
Confounders for Symbol Digit Modalities Test: brain parenchymal fraction, WM fraction, WM lesion fraction; Controlled Word Association Test: WM fraction, WM lesion fraction, gray matter fraction; and Paced Auditory Serial Addition Test: brain parenchymal fraction, WM fraction, WM lesion fraction.
NAWM rR continues to be significantly lower in the impaired group for both the Symbol Digit Modalities Test and the Paced Auditory Serial Addition Test.