Perinatal variables and grade of global brain abnormality in VPT infants
| Variables | Global Brain Abnormality | P Value | |||
|---|---|---|---|---|---|
| Normal (Score 0–3) n = 18 | Mild (Score 4–7) n = 45 | Moderate (Score 8–11) n = 21 | Severe (Score ≥12) n = 13 | ||
| Gestation at birth (weeks) | 27.4 (1.5) | 26.9 (1.6) | 25.9 (1.7) | 26.2 (2.5) | .03 |
| Birth weight (g) | 1067 (222) | 992 (235) | 789 (185) | 897 (305) | .002 |
| Birth weight < −2 SD | 1 (6%) | 3 (7%) | 1 (5%) | 1 (8%) | .99 |
| Male sex | 9 (50%) | 22 (49%) | 6 (29%) | 6 (46%) | .43 |
| Singleton | 9 (50%) | 13 (29%) | 6 (29%) | 5 (39%) | .40 |
| Critical Risk Index for Babies score | 1 [1–4] | 2 [1–5.5] | 4 [1.5–7.5] | 4 [1–9] | .06 |
| Days of intubation | 1 [0.75–2.25] | 2 [1–8.5] | 4 [1–28] | 21 [3.5–52.5] | .004 |
| Oxygen at 36 weeks | 5 (28%) | 23 (51%) | 12 (57%) | 9 (69%) | .12 |
| Postnatal steroid use | 0 | 9 (20%) | 10 (48%) | 7 (54%) | .001 |
| Inotrope use | 1 (6%) | 12 (27%) | 11 (52%) | 9 (69%) | <.001 |
| Patent ductus arteriosus | 5 (28%) | 14 (31%) | 11 (52%) | 9 (69%) | .04 |
| Total parenteral nutrition | 10.5 [9–16.5] | 16 [12.5–26.5] | 29 [14.5–47] | 25 [10–36] | .004 |
| Chorioamnionitis | 5 (28%) | 19 (42%) | 9 (45%) | 4 (31%) | .61 |
| Confirmed sepsis | 2 (11%) | 10 (22%) | 9 (43%) | 8 (62%) | .007 |
| Necrotizing enterocolitis | 0 | 2 (4%) | 3 (14%) | 2 (15%) | .19 |
Note:—Data are mean (SD), number (%), or median [lower-upper quartile].