Table 1:

Volumetric regional gray matter differences in patients with clinically isolated syndrome compared with patients with early relapsing-remitting multiple sclerosis^a

	CIS (n = 212) (mean) (SD)	Early RRMS (n = 177) (mean) (SD)	Volumetric Differences between CIS and Early RRMS^b
	CIS (n = 212) (mean) (SD)	Early RRMS (n = 177) (mean) (SD)	% Difference	SED	P Value	Adjusted P Value
NCV	614.24 (33.11)	609.41 (38.69)	−0.79	3.64	.186	.532
Total SDGMV	63.24 (3.93)	61.9 (5.12)	−2.12	0.46	.004	.001
Caudate	9.33 (1.00)	8.96 (1.03)	−3.97	0.1	<.0001	<.0001
Putamen	13.29 (1.04)	13.04 (1.32)	−1.88	0.12	.040	.051
Globus pallidus	4.74 (0.36)	4.66 (0.93)	−1.69	0.04	.022	.01
Thalamus	21.25 (1.50)	20.42 (1.97)	−3.91	0.18	<.0001	<.0001
Hippocampus	9.83 (0.94)	10.02 (1.10)	1.93	0.1	.068	.251
Amygdala	3.52 (0.44)	3.56 (0.42)	1.14	0.04	.416	.523
Nucleus accumbens	1.3 (0.24)	1.27 (0.26)	−2.31	0.03	.228	.213

Note:—SDGMV indicates subcortical deep gray matter volume; SED, standard error of difference.
↵a All volumes are reported in milliliters.
↵b Student t test and analysis of variance were used to assess volumetric differences between CIS and RRMS groups.