Table 2:

Correlation between HDWM DA or callosal parameters and cognitive scores evaluated with multiple regression analysesa

MMSEFABVFTWMSR
HDWM DA
    FA250.76b0.79b0.64c0.72b
    Mean FA0.71b0.73b0.56d0.66c
    MD25−0.99b−0.89b−0.59e−0.83b
    Mean MD−0.91b−0.78b−0.52f−0.86b
Callosal mean FA0.80b0.85b0.70b0.73g
Callosal mean MD−0.74b−0.66b−0.59g,h−0.82b
Callosal volume0.74b0.8b0.72b0.63f

  • ↵a Figures are standardized regression coefficients between each of the HDWM DA or callosal parameters and each of the cognitive scores, adjusted for age, sex, WML volume, and white matter volume.

  • ↵b Significant after Bonferroni correction (P < .05/28 = .0018).

  • ↵c P = .002.

  • ↵d P = .006.

  • ↵e P = .02.

  • ↵f P = .03.

  • ↵g P = .003.

  • ↵h White matter volume showed a weak contribution to the correlation between callosal MD and VFT (standard regression coefficient, 0.43; P =.046).