Specificity in the blinded evaluation
Dose Group and Postdose Time Point | Total Lymph Nodes | Sequence Specificity (%) | ||
---|---|---|---|---|
T2-Weighted | FFE-25 | FFE-80 | ||
1.1 mg Fe/kg | ||||
6 h | 38 | 45 | 16* | 37 |
12 h | 38 | 11 | 40† | 47 |
24 h | 38 | 29 | 53 | 66 |
36 h | 38 | 14* | 50 | 50 |
1.7 mg Fe/kg | ||||
6 h | 25 | 60 | 52 | 52 |
12 h | 25 | 80 | 32 | 68 |
24 h | 25 | 88 | 48 | 64 |
36 h | 25 | 80 | 48 | 64 |
2.6 mg Fe/kg | ||||
6 h | 26 | 88 | 42 | 50 |
12 h | 26 | 81 | 58 | 54 |
24 h | 26 | 88 | 73 | 85 |
36 h | 26 | 88 | 85 | 88 |
3.4 mg Fe/kg | ||||
6 h | 20 | 60 | 55 | 35 |
12 h | 20 | 70 | 70 | 80 |
24 h | 20 | 75 | 95 | 95 |
36 h | 20 | 75 | 100 | 80 |
Note.— The specificity was based on the signal intensity and lymph node architecture. A decrease in the signal intensity of a heterogeneous lymph node indicated a false-positive result.
* The total number of lymph nodes was 37.
† The total number of lymph nodes was 35.