Recent examples of applications in molecular neuroimaging using gene marking (of trafficking cells)
| Type of Cell Marked | Method of Gene Marking | Transplant Site | Animal Model | Imaging Method | Application | Reference |
|---|---|---|---|---|---|---|
| Viruses | Ex vivo | Intravenous, or intranasal | Mice | Fluc BLI | Evaluation of effects of interferons on vaccinia viral spread to the brain | 26 |
| Viruses | Ex vivo | Intravenous | Mice | Fluc BLI | Evaluation of factors relating to Sindbis viral spread to the brain | 27 |
| Viruses | Ex vivo | Intravenous | Mice | Fluc BLI, Rluc BLI | Evaluation of effects of valacyclovir on HSV-1 viral spread to the brain and eyes | 28 |
| Malaria parasites in RBCs | Ex vivo | Intravenous | Mice, rats | Fluc BLI | Evaluation of biology of parasite sequestration in cerebral malaria | 29 |
| Cancer cells | Ex vivo | Intravenous | Mice | Fluc BLI | Evaluation of breast cancer metastasis to brain | 30 |
| Stem cells | Ex vivo | Orthotopic | Mice | Fluc BLI | Evaluation of trafficking of stem cells to brain tumors | 31 |
| Stem cells | Ex vivo | Orthotopic | Mice | Fluc BLI | Evaluation of trafficking of stem cells to brain tumors | 32 |
| Fluc BLI | Evaluation of effect of stem cell-delivered chemotherapy on tumor burden | |||||
| Stem cells | Ex vivo | Orthotopic | Mice | Fluc BLI | Evaluation of trafficking of stem cells to brain infarcts | 33 |
| Stem cells | Ex vivo | Orthotopic | Mice | Fluc BLI | Evaluation of trafficking of stem cells to ischemic brain in relation to immune status and host immunity | 34 |
| Stem cells | Ex vivo | Orthotopic | Mice | Fluc BLI | Evaluation of trafficking of stem cells to injured spinal cord | 35 |
Note:—BLI indicates bioluminescence imaging; RBC, red blood cells; Rluc, Renilla luciferase.