Summary of reported cases of Moyamoya syndrome in association with Graves disease
Study | Age/Sex (y) | Race | Clinical Presentations | Cerebral Angiographic Findings | Outcome |
---|---|---|---|---|---|
Kushima et al3 | 26/F | Japanese | Thyrotoxicosis, recurrent hemiparesis, speech disturbance | Typical netlike vessels at the base of brain, occlusion of right ACA and MCA | Recovery |
Kushima et al3 | 22/F | Japanese | Thyrotoxicosis, hemiparesis | Narrowing of bilateral ICA, netlike vessels at the base of brain | Recovery |
Liu et al4 | 28/F | Chinese | Thyrotoxicosis, hemiparesis | Bilateral ACA and MCA occlusion with Moyamoya vessels, tubular stenosis of bilateral cervical ICA | Not described |
Tendler et al5 | 37/F | Hispanic | Thyrotoxicosis, hemiparesis | Right distal ICA, proximal MCA, and ACA occlusion, collateral from PCA | Recovery |
Tendler et al5 | 47/F | Caucasian | Moyamoya disease was diagnosed 10 years before thyrotoxicosis | Bilateral MCA occlusion, “puff of smoke” vessels on left basal ganglia | Recovery |
Leno et al6 | 21/M | Hispanic | Down syndrome, hemiparesis, thyrotoxicosis | Marked stenoses of both supraclinoid ICA, decreased flow over MCA, occluded ACA, prominent lenticulostrates | Recovery |
Kim et al7 | 37/F | Korean | Thyrotoxicosis, cardiomegaly, pulmonary edema, seizure | Bilateral ICA and left MCA occlusion (by MR angiography) | Recovery |
Nakamura et al 8 | 23/F | Japanese | Thyrotoxicosis, cardiomegaly, cerebral infarction | Multiple intracranial arterial stenoses, netlike collaterals around circle of Willis | Recovery after revasculization |
Nakamura et al8 | 54/F | Japanese | Upper limits of normal range of thyroid function, hemiparesis | Multiple intracranial arterial stenosis around circle of Willis | Recovery after revasculization |
Hsu et al (this study) | 40/F | Caucasian | Thyrotoxicosis, rapid progressive bilateral cerebral infarction | Bilateral distal ICA and proximal MCA and ACA occlusion | Died |
Note:—ACA indicates anterior cerebral artery; MCA, middle cerebral artery; ICA, internal carotid artery; PCA, posterior cerebral artery.