Table 3:

Relationship between cognition (MMSE) and vascular risk factors

	Univariable Linear Regression		Multivariable Linear Regression
Clinical Variables	β	95% CI	P	β	95% CI	P
Age	−0.19	−0.24 to − 0.14	<.001	−0.14	−0.19 to − 0.09	<.001
Sex, male	0.87	−0.14 – 1.88	.09	1.5	0.55 – 2.45	.002
Hypertension	−0.33	−1.31 – 0.66	.52
Diabetes	−1.15	−2.26 to − 0.04	.043	−0.41	−1.5 – 0.68	.47
Hyperlipidemia	1.51	0.52 – 2.51	.003	1.88	0.96 – 2.81	<.001
BMI (kg/m²)	0.09	−0.07 – 0.26	.27
Total cholesterol (mg/dL)	0.02	0.003 – 0.03	.014	0.01	−0.003 – 0.02	.14
Triglyceride (mg/dL)	0.004	−0.004 – 0.01	.27
HDL (mg/dL)	0.03	−0.01 – 0.07	.15
LDL (mg/dL)	−0.001	−0.02 – 0.02	.87
WMH burden (%)	−0.29	−0.38 to − 0.19	<.001	−0.17	−0.27 to − 0.08	<.001
Total CMB (No)	−0.014	−0.03 to − 0.006	.006	−0.01	−0.02 to − 0.001	.04