Table 1:

Imaging findings in fetal schizencephaly

FindingsFindings
Closed schizencephaly5/22 (22.7)ICH11/22 (50)
Open schizencephaly16/22 (72.7) IPH9/22 (40.9)
Both open and closed schizencephaly1/22 (4.5) Intraventricular hemorrhage5/21 (23.8)e
Multiple schizencephaly8/22 (36.4)Abnormal CC10/20 (50)d
Bilateral schizencephaly7/22 (31.8) Absent CC4/10 (40)
Overlying membranea16/34 (47.1) Hypogenetic or thin CC6/10 (60)
Median size of open defect (IQR) (mm)6 (3–19.5)Abnormal SP leaflets7/20 (35)d
Lobes involved per patientb Completely absent4/7 (57.1)
 Frontal13/22 (59.1) Partially absent3/7 (42.8)
 Parietal10/22 (45.4)Other CM13/22 (59.0)
 Temporal9/22 (40.9) Polymicrogyria9/22 (40.9)c
 Occipital11/22 (50) PVNH9/22 (40.9)
 >1 lobe involved11/22 (50)Abnormal deep gray nuclei8/21 (38.1)e
Lobes involved per defectb,a Hemorrhage6/8 (75)
 Frontal16/34 (47.1) Small size4/8 (50)
 Parietal10/34 (29.4)Abnormal brainstem7/22 (31.8)
 Temporal11/34 (32.3) Hypoplastic4/7 (57.1)
 Occipital11/34 (32.3) Dysplastic1/7 (14.3)
 >1 lobes involved7/34 (20.6) Hemorrhage1/7 (14.3)
Vascular territoryb Displaced (by cyst or schizencephaly membrane)2/7 (28.6)
 MCA23/34 (67.6)Abnormal cerebellum/vermis10/22 (45.5)
 PCA9/34 (26.5) Hypoplastic8/10 (80)
 MCA-ACA watershed2/34 (5.9) Hemorrhage2/10 (20)
Ventriculomegaly17/22 (77.2) Displaced (by cyst or schizencephaly membrane)2/10 (20)
 Unilateral9/17 (52.9)
 Mild8/17 (47.1)
 Moderate5/17 (29.4)
 Severe4/17 (23.5)
  • Note:—PCA indicates posterior cerebral artery; ACA, anterior cerebral artery.

  • a Assessed per lesion.

  • b Sum >denominator because multiple lobes were involved in many fetuses.

  • c Remote from site of schizencephaly defect.

  • d Could not be assessed in 2 fetuses.

  • e Could not be assessed in 1 fetus.