Characteristics and results of the cases with diffuse astrocytoma MYB/MYBL1–altered or angiocentric glioma, CNS WHO grade 1
Case | Age (yr) | Subgroup | Fusion/Methylation Analysis | T2-FLAIR Mismatch Sign (S) or Area (A) | Histology | |
---|---|---|---|---|---|---|
Microcysts | Enlarged Intercellular Spaces | |||||
1 | 1.1 | Diffuse Astro. | MYBL1::MMP16 | + (A) | – | – |
2 | 3.2 | Diffuse Astro. | MYBL1::STAU2-AS1 | + (S) | – | – |
3 | 9.7 | Diffuse Astro. | MYBL1::PACRG | + (S) | + | + |
4 | 9.0 | Angio-centric glioma | No fusion analysisa | + (A) | – | + |
5 | 3.9 | Diffuse Astro. | MYBL1::TOX | + (S) | + | + |
6 | 11.4 | Diffuse Astro. | No fusion analysis, diagnosis based on methylome profile | + (A) | – | + |
7 | 4.4 | Diffuse Astro. | No fusion analysisa | + (A) | – | + |
8 | 15.9 | Angio-centric glioma | MYB::QKI | – | – | – |
9 | 5.7 | Diffuse Astro. | No fusion analysisa | – | – | + |
10 | 9.6 | Diffuse Astro. | No fusion analysisa | – | – | + |
11 | 8.2 | Angio-centric glioma | MYB::QKI | + (A) | – | – |
Note:—The + indicates presence; −, absence of the characteristic; Astro. astrocytoma.
↵a In case no fusion analysis was available, the diagnosis of diffuse astrocytoma, MYB- or MYBL1–altered or angiocentric glioma was based on results of histology in combination with methylome profiling using the Infinium MethylationEPIC (850k) BeadChip (Illumina, San Diego, CA) methylation array.