Table 1:

Characteristics and results of the cases with diffuse astrocytoma MYB/MYBL1–altered or angiocentric glioma, CNS WHO grade 1

CaseAge (yr)SubgroupFusion/Methylation AnalysisT2-FLAIR Mismatch Sign (S) or Area (A)Histology
MicrocystsEnlarged Intercellular Spaces
11.1Diffuse Astro.MYBL1::MMP16+ (A)
23.2Diffuse Astro.MYBL1::STAU2-AS1+ (S)
39.7Diffuse Astro.MYBL1::PACRG+ (S)++
49.0Angio-centric gliomaNo fusion analysisa+ (A)+
53.9Diffuse Astro.MYBL1::TOX+ (S)++
611.4Diffuse Astro.No fusion analysis, diagnosis based on methylome profile+ (A)+
74.4Diffuse Astro.No fusion analysisa+ (A)+
815.9Angio-centric gliomaMYB::QKI
95.7Diffuse Astro.No fusion analysisa+
109.6Diffuse Astro.No fusion analysisa+
118.2Angio-centric gliomaMYB::QKI+ (A)
  • Note:—The + indicates presence; −, absence of the characteristic; Astro. astrocytoma.

  • a In case no fusion analysis was available, the diagnosis of diffuse astrocytoma, MYB- or MYBL1–altered or angiocentric glioma was based on results of histology in combination with methylome profiling using the Infinium MethylationEPIC (850k) BeadChip (Illumina, San Diego, CA) methylation array.