PT  - JOURNAL ARTICLE
AU  - Pantano, P.
AU  - Totaro, P.
AU  - Fabbrini, G.
AU  - Raz, E.
AU  - Contessa, G.M.
AU  - Tona, F.
AU  - Colosimo, C.
AU  - Berardelli, A.
TI  - A Transverse and Longitudinal MR Imaging Voxel-Based Morphometry Study in Patients with Primary Cervical Dystonia
AID  - 10.3174/ajnr.A2242
DP  - 2011 Jan 01
TA  - American Journal of Neuroradiology
PG  - 81--84
VI  - 32
IP  - 1
4099  - http://www.ajnr.org/content/32/1/81.short
4100  - http://www.ajnr.org/content/32/1/81.full
SO  - Am. J. Neuroradiol.2011 Jan 01; 32
AB  - BACKGROUND AND PURPOSE: Findings of standard MR imaging examinations are usually normal in primary CD. These findings are now increasingly challenged by studies using advanced neuroimaging techniques detecting abnormalities in brain areas that may be functionally involved in the pathophysiology of CD. Our purpose was to evaluate GM volumes in patients with CD at baseline and 5 years later. MATERIALS AND METHODS: We enrolled 19 patients (F/M = 15:4, mean age = 53.2 + 11.2 years), 12 of whom were studied at baseline and again approximately 5 years later. Twenty-eight healthy volunteers acted as controls (F/M = 17:11, mean age = 47.5 + 15.6 years). The subjects were imaged with a 1.5T scanner by using a 3D T1-weighted sequence on 150 contiguous axial 1-mm-thick sections to apply VBM. RESULTS: At entry, VBM analysis disclosed significantly lower GM volumes in the left caudate head and putamen and in the premotor and primary sensorimotor cortices bilaterally in patients than in controls. No correlation was found between decreased GM volumes and patient age, severity of dystonia, or disease duration. At the 5-year follow-up, GM volumes in the left primary sensorimotor cortex in patients had decreased significantly from baseline. CONCLUSIONS: The findings obtained at entry and after a 5-year follow-up consistently showed decreased caudate, putamen, and sensorimotor cortex GM volumes in patients with CD, and they probably play a pathophysiologic role in CD. CDcervical dystoniaDTIdiffusion tensor imagingFfemaleFDRfalse discovery rateGMgray matterGPiinternal segment of globus palliduskvoxel per clusterLleftMmaleMNIMontreal Neurological InstitutemomonthsMRIMR imagingNAnot availableRrightSMAsupplementary motor areaSPMStatistical Parametric MappingVBMvoxel-based morphometryWMwhite matteryryears