RT Journal Article
SR Electronic
T1 Cytotoxic Lesions of the Corpus Callosum Caused by Thermogenic Dietary Supplements
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1304
OP 1308
DO 10.3174/ajnr.A6116
VO 40
IS 8
A1 Galnares-Olalde, J.A.
A1 Vázquez-Mézquita, A.J.
A1 Gómez-Garza, G.
A1 Reyes-Vázquez, D.
A1 Higuera-Ortiz, V.
A1 Alegría-Loyola, M.A.
A1 Mendez-Dominguez, A.
YR 2019
UL http://www.ajnr.org/content/40/8/1304.abstract
AB SUMMARY: Consumption of over-the-counter dietary supplements to reduce body weight is common among the population. Thermogenics are herbal combinations that claim to produce a fat-burning process through an increase in the cellular metabolic rate and greater cellular energy consumption, having a high risk for patients developing toxic leukoencephalopathy. We present a series of 6 patients with acute neurologic symptoms and MR imaging showing restricted diffusion and decreased apparent diffusion coefficient values (mean value, 400 mm2/s × 10−6) in the entire corpus callosum compatible with a cytotoxic lesion of the corpus callosum. Although patients responded favorably to the product discontinuation with rapid recovery of neurologic symptoms, there was a more prolonged resolution on imaging alterations. Because of the widespread availability and unregulated nature of thermogenic dietary supplements, physicians must be aware of the clinical and radiologic characteristics of these potential complications of their use.CLOCCcytotoxic lesion of the corpus callosum