RT Journal Article
SR Electronic
T1 High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 366
OP 369
DO 10.3174/ajnr.A5888
VO 40
IS 2
A1 Spyris, C.D.
A1 Castellino, R.C.
A1 Schniederjan, M.J.
A1 Kadom, N.
YR 2019
UL http://www.ajnr.org/content/40/2/366.abstract
AB SUMMARY: High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.HGGhigh-grade gliomaLGGlow-grade gliomaNF1neurofibromatosis type 1