PT  - JOURNAL ARTICLE
AU  - Wongsripuemtet, J.
AU  - Tyan, A.E.
AU  - Carass, A.
AU  - Agarwal, S.
AU  - Gujar, S.K.
AU  - Pillai, J.J.
AU  - Sair, H.I.
TI  - Preoperative Mapping of the Supplementary Motor Area in Patients with Brain Tumor Using Resting-State fMRI with Seed-Based Analysis
AID  - 10.3174/ajnr.A5709
DP  - 2018 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1493--1498
VI  - 39
IP  - 8
4099  - http://www.ajnr.org/content/39/8/1493.short
4100  - http://www.ajnr.org/content/39/8/1493.full
SO  - Am. J. Neuroradiol.2018 Aug 01; 39
AB  - BACKGROUND AND PURPOSE: The supplementary motor area can be a critical region in the preoperative planning of patients undergoing brain tumor resection because it plays a role in both language and motor function. While primary motor regions have been successfully identified using resting-state fMRI, there is variability in the literature regarding the identification of the supplementary motor area for preoperative planning. The purpose of our study was to compare resting-state fMRI to task-based fMRI for localization of the supplementary motor area in a large cohort of patients with brain tumors presenting for preoperative brain mapping.MATERIALS AND METHODS: Sixty-six patients with brain tumors were evaluated with resting-state fMRI using seed-based analysis of hand and orofacial motor regions. Rates of supplementary motor area localization were compared with those in healthy controls and with localization results by task-based fMRI.RESULTS: Localization of the supplementary motor area using hand motor seed regions was more effective than seeding using orofacial motor regions for both patients with brain tumor (95.5% versus 34.8%, P < .001) and controls (95.2% versus 45.2%, P < .001). Bilateral hand motor seeding was superior to unilateral hand motor seeding in patients with brain tumor for either side (95.5% versus 75.8%/75.8% for right/left, P < .001). No difference was found in the ability to identify the supplementary motor area between patients with brain tumors and controls.CONCLUSIONS: In addition to task-based fMRI, seed-based analysis of resting-state fMRI represents an equally effective method for supplementary motor area localization in patients with brain tumors, with the best results obtained with bilateral hand motor region seeding.DCSdirect cortical stimulationrs-fMRIresting-state fMRISMAsupplementary motor areatb-fMRItask-based fMRI