RT Journal Article
SR Electronic
T1 Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New “Leave Me Alone” Lesion with a Characteristic Imaging Pattern
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1899
OP 1904
DO 10.3174/ajnr.A5281
VO 38
IS 10
A1 Nunes, R.H.
A1 Hsu, C.C.
A1 da Rocha, A.J.
A1 do Amaral, L.L.F.
A1 Godoy, L.F.S.
A1 Watkins, T.W.
A1 Marussi, V.H.
A1 Warmuth-Metz, M.
A1 Alves, H.C.
A1 Goncalves, F.G.
A1 Kleinschmidt-DeMasters, B.K.
A1 Osborn, A.G.
YR 2017
UL http://www.ajnr.org/content/38/10/1899.abstract
AB SUMMARY: Multinodular and vacuolating neuronal tumor of the cerebrum is a recently reported benign, mixed glial neuronal lesion that is included in the 2016 updated World Health Organization classification of brain neoplasms as a unique cytoarchitectural pattern of gangliocytoma. We report 33 cases of presumed multinodular and vacuolating neuronal tumor of the cerebrum that exhibit a remarkably similar pattern of imaging findings consisting of a subcortical cluster of nodular lesions located on the inner surface of an otherwise normal-appearing cortex, principally within the deep cortical ribbon and superficial subcortical white matter, which is hyperintense on FLAIR. Only 4 of our cases are biopsy-proven because most were asymptomatic and incidentally discovered. The remaining were followed for a minimum of 24 months (mean, 3 years) without interval change. We demonstrate that these are benign, nonaggressive lesions that do not require biopsy in asymptomatic patients and behave more like a malformative process than a true neoplasm.DNETdysembryoplastic neuroepithelial tumorMVNTmultinodular and vacuolating neuronal tumor of the cerebrum