PT  - JOURNAL ARTICLE
AU  - Nunes, R.H.
AU  - Hsu, C.C.
AU  - da Rocha, A.J.
AU  - do Amaral, L.L.F.
AU  - Godoy, L.F.S.
AU  - Watkins, T.W.
AU  - Marussi, V.H.
AU  - Warmuth-Metz, M.
AU  - Alves, H.C.
AU  - Goncalves, F.G.
AU  - Kleinschmidt-DeMasters, B.K.
AU  - Osborn, A.G.
TI  - Multinodular and Vacuolating Neuronal Tumor of the Cerebrum: A New “Leave Me Alone” Lesion with a Characteristic Imaging Pattern
AID  - 10.3174/ajnr.A5281
DP  - 2017 Oct 01
TA  - American Journal of Neuroradiology
PG  - 1899--1904
VI  - 38
IP  - 10
4099  - http://www.ajnr.org/content/38/10/1899.short
4100  - http://www.ajnr.org/content/38/10/1899.full
SO  - Am. J. Neuroradiol.2017 Oct 01; 38
AB  - SUMMARY: Multinodular and vacuolating neuronal tumor of the cerebrum is a recently reported benign, mixed glial neuronal lesion that is included in the 2016 updated World Health Organization classification of brain neoplasms as a unique cytoarchitectural pattern of gangliocytoma. We report 33 cases of presumed multinodular and vacuolating neuronal tumor of the cerebrum that exhibit a remarkably similar pattern of imaging findings consisting of a subcortical cluster of nodular lesions located on the inner surface of an otherwise normal-appearing cortex, principally within the deep cortical ribbon and superficial subcortical white matter, which is hyperintense on FLAIR. Only 4 of our cases are biopsy-proven because most were asymptomatic and incidentally discovered. The remaining were followed for a minimum of 24 months (mean, 3 years) without interval change. We demonstrate that these are benign, nonaggressive lesions that do not require biopsy in asymptomatic patients and behave more like a malformative process than a true neoplasm.DNETdysembryoplastic neuroepithelial tumorMVNTmultinodular and vacuolating neuronal tumor of the cerebrum