PT - JOURNAL ARTICLE AU - Sullivan, M E AU - Goldstein, H A AU - Sansone, K J AU - Stoner, S A AU - Holyoak, W L AU - Wiggins, J R TI - Hemodynamic effects of Gd-DTPA administered via rapid bolus or slow infusion: a study in dogs. DP - 1990 May 01 TA - American Journal of Neuroradiology PG - 537--540 VI - 11 IP - 3 4099 - http://www.ajnr.org/content/11/3/537.short 4100 - http://www.ajnr.org/content/11/3/537.full SO - Am. J. Neuroradiol.1990 May 01; 11 AB - The hemodynamic effects of rapid (10 sec) versus slow (1 min) IV injection of Gd-DTPA were compared in normal, pentobarbital-anesthetized mongrel dogs. Hypertonic mannitol and isotonic saline were used as equiosmotic and equivolumetric controls. Two dose levels of Gd-DTPA were administered: 0.1 mmol/kg and 0.5 mmol/kg, corresponding to dose volumes of 0.2 and 1.0 ml/kg, respectively. The rapid injection of a high dose (0.5 mmol/kg) produced a transient decrease in arterial blood pressure (21 mm Hg, p less than .001), which returned to control values within 1 min after the injection. Slow IV infusion at this high dose had no statistically significant hemodynamic effects. There were no statistically significant effects of the lower dose (0.1 mmol/kg) administered as a bolus or by infusion, nor of the saline or osmotic control solutions. These results suggest that acute hemodynamic effects of Gd-DTPA are not observed at clinically relevant doses and the vasodilation observed at a higher dose may result from a direct action of the contrast agent.