PT  - JOURNAL ARTICLE
AU  - Klaming, R.
AU  - Annese, J.
TI  - Functional Anatomy of Essential Tremor: Lessons from Neuroimaging
AID  - 10.3174/ajnr.A3586
DP  - 2014 Aug 01
TA  - American Journal of Neuroradiology
PG  - 1450--1457
VI  - 35
IP  - 8
4099  - http://www.ajnr.org/content/35/8/1450.short
4100  - http://www.ajnr.org/content/35/8/1450.full
SO  - Am. J. Neuroradiol.2014 Aug 01; 35
AB  - SUMMARY: The neuropathogenetic processes underlying essential tremor appear to cause subtle morphologic changes in neural networks that include multiple brain structures, primarily the cerebellum, brain stem, frontal lobes, and thalamus. One of the main challenges of neuroimaging in essential tremor is differentiating disease-specific markers from the spectrum of structural changes that occur due to aging. This review discusses recent neuroimaging studies in the light of current knowledge of the neuropsychology and pathology of the disease. We suggest that the application of multiple macroscopic and microscopic neuroimaging modalities, combined with personalized information relative to cognitive and behavioral symptoms, is the prerequisite for a comprehensive classification and correct diagnosis of essential tremor. ETessential tremor