RT Journal Article
SR Electronic
T1 Brain Nuclear Magnetic Resonance Imaging Enhanced by a Paramagnetic Nitroxide Contrast Agent: Preliminary Report
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 1035
OP 1039
VO 4
IS 5
A1 Brasch, Robert C.
A1 Nitecki, Danute E.
A1 Brant-Zawadzki, Michael
A1 Enzmann, Dieter R.
A1 Wesbey, George E.
A1 Tozer, Thomas N.
A1 Tuck, L. Dallas
A1 Cann, Christopher E.
A1 Fike, John R.
A1 Sheldon, Phillip
YR 1983
UL http://www.ajnr.org/content/4/5/1035.abstract
AB Contrast-enhancing agents for demonstrating abnormalities of the blood-brain barrier may extend the diagnostic utility of proton nuclear magnetic resonance (NMR) imaging. “TES,” a nitroxide stable free radical derivative, was tested as a central nervous system contrast enhancer in dogs with experimentally induced unilateral cerebritis or radiation cerebral damage. After intravenous injection of TES, the normal brain showed no change in NMR appearance, but areas of disease demonstrated a dramatic increase (up to 45%) in spin-echo intensity and a decrease in T1, relaxation times. The areas of disease defined by TES enhancement were either not evident on the nonenhanced NMR images or were better defined after contrast administration. In-depth tests of toxicity, stability, and metabolism of this promising NMR contrast agent are now in progress.