PT  - JOURNAL ARTICLE
AU  - Rai, Pranjal
AU  - Soni, Neetu
AU  - Bathla, Girish
AU  - Raj, Karuna
AU  - Desai, Amit
AU  - Gupta, Vivek
AU  - Agarwal, Amit
TI  - Light-Chain Deposition Diseases of the CNS: Review of Pathogenesis, Imaging Features, and Radiographic Mimics
AID  - 10.3174/ajnr.A8390
DP  - 2025 Apr 01
TA  - American Journal of Neuroradiology
PG  - 659--665
VI  - 46
IP  - 4
4099  - http://www.ajnr.org/content/46/4/659.short
4100  - http://www.ajnr.org/content/46/4/659.full
SO  - Am. J. Neuroradiol.2025 Apr 01; 46
AB  - Light-chain deposition disease (LCDD) is a rare CNS disorder characterized by the extracellular accumulation of monoclonal immunoglobulin light chains in various organs. LCDD typically arises secondary to an underlying plasma cell dyscrasia, such as monoclonal gammopathy of undetermined significance or multiple myeloma. However, rare cases can occur in the absence of a demonstrable plasma cell disorder. The kidneys, liver, lungs, and heart are the most affected organs. Intracerebral LCDD, particularly without an underlying plasma cell neoplasm, represents an exceedingly uncommon entity with limited documented cases in the literature. This review article explores the pathogenesis, histopathologic features, and characteristic neuroimaging findings of intracerebral LCDD. We emphasize the diverse imaging presentations of this disease, which can closely resemble other neurologic pathologies. Recognizing these potential mimics is crucial for avoiding misdiagnosis, especially in the absence of a known underlying plasma cell disorder. This article aims to provide a comprehensive overview from a neuroradiologic perspective, facilitating the recognition and differentiation of this challenging entity.ALDamyloidomaIgimmunoglobulinLClight chainLCDDlight-chain deposition diseaseMIDDmonoclonal immunoglobulin deposition disease