PT  - JOURNAL ARTICLE
AU  - Inglese, Matilde
AU  - Horsfield, Mark A.
AU  - Filippi, Massimo
TI  - Scan-Rescan Variation of Measures Derived from Brain Magnetization Transfer Ratio Histograms Obtained in Healthy Volunteers by Use of a Semi-interleaved Magnetization Transfer Sequence
DP  - 2001 Apr 01
TA  - American Journal of Neuroradiology
PG  - 681--684
VI  - 22
IP  - 4
4099  - http://www.ajnr.org/content/22/4/681.short
4100  - http://www.ajnr.org/content/22/4/681.full
SO  - Am. J. Neuroradiol.2001 Apr 01; 22
AB  - Summary: A novel semiinterleaved gradient-echo (GE) sequence for quantitative measurement of magnetization transfer ratio (MTR) is described. With this sequence, several lines of k-space are collected for the non-MT image then several lines are collected for the MT image, thus building up the entire k-space in distinct acquisition blocks, with a good trade-off between motion-induced misregistration and degree of MT effect. The scan-rescan coefficients of variation for several MTR histogram-derived measures from 10 healthy volunteers scanned serially with this semiinterleaved sequence proved to be lower than those achieved using a conventional GE sequence. This sequence may be useful in a clinical environment to measure MTR changes over time more reliably than when acquiring the non-MT and MT images sequentially, which inevitably are affected by patient motion.