RT Journal Article
SR Electronic
T1 Comprehensive Review of the Utility of Dynamic Contrast-Enhanced MRI for the Diagnosis and Treatment Assessment of Spinal Benign and Malignant Osseous Disease
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
DO 10.3174/ajnr.A8398
A1 Saha, Atin
A1 Gibbs, Haley
A1 Peck, Kyung K.
A1 Yildirim, Onur
A1 Nilchian, Parsa
A1 Karimi, Sasan
A1 Lis, Eric
A1 Kosović, Vilma
A1 Holodny, Andrei I.
YR 2024
UL http://www.ajnr.org/content/early/2024/10/31/ajnr.A8398.abstract
AB Conventional MRI is currently the preferred imaging technique for detection and evaluation of malignant spinal lesions. However, this technique is limited in its ability to assess tumor viability. Unlike conventional MRI, dynamic contrast-enhanced (DCE) MRI provides insight into the physiologic and hemodynamic characteristics of malignant spinal tumors and has been utilized in different types of spinal diseases. DCE has been shown to be especially useful in the cancer setting; specifically, DCE can discriminate between malignant and benign vertebral compression fractures as well as between atypical hemangiomas and metastases. DCE has also been shown to differentiate between different types of metastases. Furthermore, DCE can be useful in the assessment of radiation therapy for spinal metastases, including the prediction of tumor recurrence. This review considers data analysis methods utilized in prior studies of DCE-MRI data acquisition and clinical implications.AIFarterial input functionAUCarea under the curveDCEdynamic contrast-enhancedEESextravascular extracellular spaceHD-IGRThigh-dose image-guided radiation therapyKepexchange rate constantKtranspermeability constantPDprogressive diseaseSCIspinal cord injurySPGRspoiled gradient recalledTICtime intensity curveVeextracellular volume fractionVpplasma volume