RT Journal Article SR Electronic T1 Malformation of Cortical and Vascular Development in One Family with Parietal Foramina Determined by an ALX4 Homeobox Gene Mutation JF American Journal of Neuroradiology JO Am. J. Neuroradiol. FD American Society of Neuroradiology SP 1836 OP 1839 VO 25 IS 10 A1 Valente, Marcelo A1 Valente, Kette D. A1 Sugayama, Sofia S. M. A1 Kim, Chong Ae YR 2004 UL http://www.ajnr.org/content/25/10/1836.abstract AB Summary: Vascular and cortical anomalies have been found in a family with parietal foramina type 2 (PFM2), which is determined by the ALX4 gene. It is believed that ALX4 has a bone-restricted expression. We report a case of PFM with age-related size variation in a 4-year-old boy, as well as in his mother, aunt and grandfather. MR imaging of the child demonstrates prominent malformations of cortical (polymicrogyric cortex with an unusual infolding pattern) and vascular development (persistence median prosencephalic vein), associated with high tentorial incisure periatrial white matter changes.