PT - JOURNAL ARTICLE AU - Valente, Marcelo AU - Valente, Kette D. AU - Sugayama, Sofia S. M. AU - Kim, Chong Ae TI - Malformation of Cortical and Vascular Development in One Family with Parietal Foramina Determined by an <em>ALX4</em> Homeobox Gene Mutation DP - 2004 Nov 01 TA - American Journal of Neuroradiology PG - 1836--1839 VI - 25 IP - 10 4099 - http://www.ajnr.org/content/25/10/1836.short 4100 - http://www.ajnr.org/content/25/10/1836.full SO - Am. J. Neuroradiol.2004 Nov 01; 25 AB - Summary: Vascular and cortical anomalies have been found in a family with parietal foramina type 2 (PFM2), which is determined by the ALX4 gene. It is believed that ALX4 has a bone-restricted expression. We report a case of PFM with age-related size variation in a 4-year-old boy, as well as in his mother, aunt and grandfather. MR imaging of the child demonstrates prominent malformations of cortical (polymicrogyric cortex with an unusual infolding pattern) and vascular development (persistence median prosencephalic vein), associated with high tentorial incisure periatrial white matter changes.