RT Journal Article
SR Electronic
T1 Serial Diffusion-Weighted MR Imaging and Proton MR Spectroscopy of Acute Large Demyelinating Brain Lesions: Case Report
JF American Journal of Neuroradiology
JO Am. J. Neuroradiol.
FD American Society of Neuroradiology
SP 989
OP 994
VO 23
IS 6
A1 Rovira, Alex
A1 Pericot, Imma
A1 Alonso, Juli
A1 Rio, Jordi
A1 Grivé, Elisenda
A1 Montalban, Xavier
YR 2002
UL http://www.ajnr.org/content/23/6/989.abstract
AB Summary: We present the serial MR studies of two patients with symptomatic acute large demyelinating lesions that initially showed a drop in apparent diffusion coefficient values. Baseline proton MR spectroscopy showed a slight decrease in N-acetylaspartate and a normal choline level. An excess of lactate was observed at the first examinations and completely disappeared by the final examinations.The time-course evolution of the lesions shown by MR imaging and proton MR spectroscopic examinations suggests that the initial drop in apparent coefficient diffusion may have been related to dense inflammatory cell infiltration and scant tissue destruction or to reversible reduced vascular supply due to the severity of the inflammatory process.