Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurointervention
Open Access

A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms

T.E. Darsaut, J.M. Findlay, M.W. Bojanowski, C. Chalaala, D. Iancu, D. Roy, A. Weill, W. Boisseau, A. Diouf, E. Magro, M. Kotowski, M.B. Keough, L. Estrade, N. Bricout, J.-P. Lejeune, M.M.C. Chow, C.J. O’Kelly, J.L. Rempel, R.A. Ashforth, H. Lesiuk, J. Sinclair, U.-E. Erdenebold, J.H. Wong, F. Scholtes, D. Martin, B. Otto, A. Bilocq, E. Truffer, K. Butcher, A.J. Fox, A.S. Arthur, L. Létourneau-Guillon, F. Guilbert, M. Chagnon, J. Zehr, B. Farzin, G. Gevry and J. Raymond
American Journal of Neuroradiology May 2023, DOI: https://doi.org/10.3174/ajnr.A7865
T.E. Darsaut
aFrom the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for T.E. Darsaut
J.M. Findlay
aFrom the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.M. Findlay
M.W. Bojanowski
cService of Neurosurgery (M.W.B., C.C.), Department of Surgery
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.W. Bojanowski
C. Chalaala
cService of Neurosurgery (M.W.B., C.C.), Department of Surgery
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C. Chalaala
D. Iancu
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Iancu
D. Roy
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Roy
A. Weill
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Weill
W. Boisseau
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for W. Boisseau
A. Diouf
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Diouf
E. Magro
eService of Neurosurgery (E.M.), Centre Hospitalier Universitaire Cavale Blanche, Institut National de la Santé et de la Recherche Médicale Unité Mixte de Recherche 1101 LaTIM, Brest, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Magro
M. Kotowski
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Kotowski
M.B. Keough
aFrom the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.B. Keough
L. Estrade
fInterventional Neuroradiology (L.E., N.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Estrade
N. Bricout
fInterventional Neuroradiology (L.E., N.B.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for N. Bricout
J.-P. Lejeune
gService of Neurosurgery (J.-P.L.), Centre Hospitalier Universitaire de Lille, Lille, France
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.-P. Lejeune
M.M.C. Chow
aFrom the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M.M.C. Chow
C.J. O’Kelly
aFrom the Division of Neurosurgery (T.E.D., J.M.F., M.B.K., M.M.C.C., C.J.O.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for C.J. O’Kelly
J.L. Rempel
bDepartment of Surgery, and Department of Radiology and Diagnostic Imaging (J.L.R., R.A.A.), Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.L. Rempel
R.A. Ashforth
bDepartment of Surgery, and Department of Radiology and Diagnostic Imaging (J.L.R., R.A.A.), Mackenzie Health Sciences Centre, University of Alberta Hospital, Edmonton, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R.A. Ashforth
H. Lesiuk
hSection of Neurosurgery (H.L., J.S.), Department of Surgery
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for H. Lesiuk
J. Sinclair
hSection of Neurosurgery (H.L., J.S.), Department of Surgery
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Sinclair
U.-E. Erdenebold
iDepartment of Medical Imaging (U.-E.E.), Section of Interventional Neuroradiology, Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for U.-E. Erdenebold
J.H. Wong
jDivision of Neurosurgery (J.H.W.), Foothills Medical Centre, University of Calgary, Calgary, Alberta, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J.H. Wong
F. Scholtes
kDepartments of Neurosurgery (F.S., D.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F. Scholtes
D. Martin
kDepartments of Neurosurgery (F.S., D.M.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for D. Martin
B. Otto
lMedical Physics (B.O.), Division of Medical Imaging, Centre Hospitalier Universitaire de Liège, Liège, Belgium
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for B. Otto
A. Bilocq
mService of Neurosurgery (A.B., E.T.), Centre Hospitalier Régional de Trois-Rivières, Trois-Rivières, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Bilocq
E. Truffer
mService of Neurosurgery (A.B., E.T.), Centre Hospitalier Régional de Trois-Rivières, Trois-Rivières, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for E. Truffer
K. Butcher
nClinical Neurosciences (K.B.), Prince of Wales Clinical School, University of New South Wales, Randwick, New SouthWales, Australia
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for K. Butcher
A.J. Fox
oDepartment of Medical Imaging (A.J.F.), University of Toronto, Toronto, Ontario, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.J. Fox
A.S. Arthur
pDepartment of Neurosurgery (A.S.A.), University of Tennessee Health Science Center and Semmes-Murphey Clinic, Memphis, Tennessee
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A.S. Arthur
L. Létourneau-Guillon
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for L. Létourneau-Guillon
F. Guilbert
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for F. Guilbert
M. Chagnon
qDepartment of Mathematics and Statistics (M.C., J.Z.), Université de Montréal, Montréal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Chagnon
J. Zehr
qDepartment of Mathematics and Statistics (M.C., J.Z.), Université de Montréal, Montréal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Zehr
B. Farzin
rResearch Centre of the University of Montreal Hospital Centre (B.F., G.G., J.R.), Interventional Neuroradiology Research Laboratory, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
G. Gevry
rResearch Centre of the University of Montreal Hospital Centre (B.F., G.G., J.R.), Interventional Neuroradiology Research Laboratory, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for G. Gevry
J. Raymond
dService of Neuroradiology (D.I., D.R., A.W., W.B., A.D., M.K., L.L.-G., F.G., J.R.), Department of Radiology, Centre Hospitalier de l’Université de Montréal, Montreal, Québec, Canada
rResearch Centre of the University of Montreal Hospital Centre (B.F., G.G., J.R.), Interventional Neuroradiology Research Laboratory, Montreal, Québec, Canada
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for J. Raymond
  • Article
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Vernooij MW,
    2. Ikram MA,
    3. Tanghe HL, et al
    . Incidental findings on brain MRI in the general population. N Engl J Med 2007;357:1821–28 doi:10.1056/NEJMoa070972 pmid:17978290
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Vlak MH,
    2. Algra A,
    3. Brandenburg R, et al
    . Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis. Lancet Neurol 2011;10:626–36 doi:10.1016/S1474-4422(11)70109-0 pmid:21641282
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Etminan N,
    2. de Sousa DA,
    3. Tiseo C, et al
    . European Stroke Organisation (ESO) guidelines on management of unruptured intracranial aneurysms. Eur Stroke J 2022;7:V doi:10.1177/23969873221099736 pmid:36082246
    CrossRefPubMed
  4. 4.↵
    1. Villablanca JP,
    2. Duckwiler GR,
    3. Jahan R, et al
    . Natural history of asymptomatic unruptured cerebral aneurysms evaluated at CT angiography: growth and rupture incidence and correlation with epidemiologic risk factors. Radiology 2013;269:258–65 doi:10.1148/radiol.13121188 pmid:23821755
    CrossRefPubMedWeb of Science
  5. 5.↵
    1. Backes D,
    2. Vergouwen MD,
    3. Tiel Groenestege AT, et al
    . PHASES score for prediction of intracranial aneurysm growth. Stroke 2015;46:1221–26 doi:10.1161/STROKEAHA.114.008198 pmid:25757900
    Abstract/FREE Full Text
  6. 6.↵
    1. Thompson BG,
    2. Brown RD Jr.,
    3. Amin-Hanjani S, et al
    ; American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, and Council on Epidemiology and Prevention; American Heart Association; American Stroke Association. Guidelines for the Management of Patients With Unruptured Intracranial Aneurysms: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association. Stroke 2015;46:2368–400 doi:10.1161/STR.0000000000000070 pmid:26089327
    Abstract/FREE Full Text
  7. 7.↵
    1. Darsaut TE,
    2. Estrade L,
    3. Jamali S, et al
    . Uncertainty and agreement in the management of unruptured intracranial aneurysms. J Neurosurg 2014;120:618–23 doi:10.3171/2013.11.JNS131366 pmid:24405069
    CrossRefPubMed
  8. 8.↵
    1. Molyneux A,
    2. Kerr R,
    3. Stratton I, et al
    ; International Subarachnoid Aneurysm Trial (ISAT) Collaborative Group. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised trial. Lancet 2002;360:1267–74 doi:10.1016/s0140-6736(02)11314-6 pmid:12414200
    CrossRefPubMedWeb of Science
  9. 9.↵
    1. Pontes FG,
    2. da Silva EM,
    3. Baptista-Silva JC, et al
    . Treatments for unruptured intracranial aneurysms. Cochrane Database Syst Rev 2021;5:CD013312 doi:10.1002/14651858.CD013312.pub2 pmid:33971026
    CrossRefPubMed
  10. 10.↵
    1. Raymond J,
    2. Darsaut TE,
    3. Molyneux AJ
    ; TEAM Collaborative Group. A trial on unruptured intracranial aneurysms (the TEAM trial): results, lessons from a failure and the necessity for clinical care trials. Trials 2011;12:64 doi:10.1186/1745-6215-12-64 pmid:21375745
    CrossRefPubMed
  11. 11.↵
    1. Kotowski M,
    2. Naggara O,
    3. Darsaut TE, et al
    . Safety and occlusion rates of surgical treatment of unruptured intracranial aneurysms: a systematic review and meta-analysis of the literature from 1990 to 2011. J Neurol Neurosurg Psychiatry 2013;84:42–48 doi:10.1136/jnnp-2011-302068 pmid:23012447
    Abstract/FREE Full Text
  12. 12.↵
    1. Darsaut TE,
    2. Findlay JM,
    3. Raymond J
    ; CURES Collaborative Group. The design of the Canadian UnRuptured Endovascular versus Surgery (CURES) trial. Can J Neurol Sci 2011;38:236–41 doi:10.1017/s0317167100011392 pmid:21320826
    CrossRefPubMedWeb of Science
  13. 13.↵
    1. Darsaut TE,
    2. Findlay JM,
    3. Magro E, et al
    . Surgical clipping or endovascular coiling for unruptured intracranial aneurysms: a pragmatic randomised trial. J Neurol Neurosurg Psychiatry 2017;88:663–68 doi:10.1136/jnnp-2016-315433 pmid:28634280
    Abstract/FREE Full Text
  14. 14.↵
    1. Darsaut TE,
    2. Desal H,
    3. Cognard C, et al
    . Comprehensive Aneurysm Management (CAM): an all-inclusive care trial for unruptured intracranial aneurysms. World Neurosurg 2020;141:e770–77 doi:10.1016/j.wneu.2020.06.018 pmid:32526362
    CrossRefPubMed
  15. 15.↵
    1. Raymond J,
    2. Darsaut TE,
    3. Roy DJ
    . Recruitment in clinical trials: the use of Zelen’s prerandomization in recent neurovascular studies. World Neurosurg 2017;98:403–10 doi:10.1016/j.wneu.2016.11.052 pmid:27876665
    CrossRefPubMed
  16. 16.↵
    1. Bruno A,
    2. Akinwuntan AE,
    3. Lin C, et al
    . Simplified modified Rankin scale questionnaire: reproducibility over the telephone and validation with quality of life. Stroke 2011;42:2276–79 doi:10.1161/STROKEAHA.111.613273 pmid:21680905
    Abstract/FREE Full Text
  17. 17.↵
    1. Benomar A,
    2. Farzin B,
    3. Gevry G, et al
    . Noninvasive angiographic results of clipped or coiled intracranial aneurysms: an inter- and intraobserver reliability study. AJNR Am J Neuroradiol 2021;42:1615–20 doi:10.3174/ajnr.A7236 pmid:34326106
    Abstract/FREE Full Text
  18. 18.↵
    1. Benomar A,
    2. Farzin B,
    3. Volders D, et al
    . Angiographic results of surgical or endovascular treatment of intracranial aneurysms: a systematic review and inter-observer reliability study. Neuroradiology 2021;63:1511–19 doi:10.1007/s00234-021-02676-0 pmid:33625550
    CrossRefPubMed
  19. 19.↵
    1. Darsaut TE,
    2. Chapot R,
    3. Raymond J
    . Changing the rules of the game: the problem of surrogate angiographic outcomes in the evaluation of aneurysm treatments. AJNR Am J Neuroradiol 2020;41:2174–75 doi:10.3174/ajnr.A6825 pmid:33033042
    FREE Full Text
  20. 20.↵
    1. White PM,
    2. Lewis SC,
    3. Gholkar A
    ; HELPS Trial Collaborators, et al. Hydrogel-Coated Coils Versus Bare Platinum Coils for the Endovascular Treatment of Intracranial Aneurysms (HELPS): a randomised controlled trial. Lancet 2011;377:1655–62 doi:10.1016/S0140-6736(11)60408-X pmid:21571149
    CrossRefPubMedWeb of Science
  21. 21.↵
    1. Raymond J,
    2. Klink R,
    3. Chagnon M, et al
    . Hydrogel versus bare platinum coils in patients with large or recurrent aneurysms prone to recurrence after endovascular treatment: a randomized controlled trial. AJNR Am J Neuroradiol 2017;38:432–41 doi:10.3174/ajnr.A5101 pmid:28082261
    Abstract/FREE Full Text
  22. 22.↵
    1. Coley S,
    2. Sneade M,
    3. Clarke A, et al
    . Cerecyte Coil Trial: procedural safety and clinical outcomes in patients with ruptured and unruptured intracranial aneurysms. AJNR Am J Neuroradiol 2012;33:474–80 doi:10.3174/ajnr.A2836 pmid:22207299
    Abstract/FREE Full Text
  23. 23.↵
    1. Darsaut TE,
    2. Raymond J
    ; STAT Collaborative Group. The design of the STenting in Aneurysm Treatments (STAT) trial. J Neurointerv Surg 2012;4:178–81 doi:10.1136/neurintsurg-2011-010065 pmid:21990519
    Abstract/FREE Full Text
  24. 24.↵
    1. Zhang Q,
    2. Jing L,
    3. Liu J, et al
    . Predisposing factors for recanalization of cerebral aneurysms after endovascular embolization: a multivariate study. J Neurointerv Surg 2018;10:252–57 doi:10.1136/neurintsurg-2017-013041 pmid:28377443
    Abstract/FREE Full Text
  25. 25.↵
    1. Lee J,
    2. Lim JW,
    3. Cho YD
    . Follow-up outcomes after re-embolization for recanalized aneurysms after initial coiling: further recurrence rates and related risk factors. World Neurosurg 2018;114:e508–17 doi:10.1016/j.wneu.2018.03.017 pmid:29530696
    CrossRefPubMed
  26. 26.↵
    1. Lecler A,
    2. Raymond J,
    3. Rodriguez-Regent C, et al
    . Intracranial aneurysms: recurrences more than 10 years after endovascular treatment: a prospective cohort study, systematic review, and meta-analysis. Radiology 2015;277:173–80 doi:10.1148/radiol.2015142496 pmid:26057784
    CrossRefPubMed
  27. 27.↵
    1. Raymond J,
    2. Guilbert F,
    3. Weill A, et al
    . Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils. Stroke 2003;34:1398–403 doi:10.1161/01.STR.0000073841.88563.E9 pmid:12775880
    Abstract/FREE Full Text
  28. 28.↵
    1. Raymond J,
    2. Darsaut TE,
    3. Altman DG
    . Pragmatic trials can be designed as optimal medical care: principles and methods of care trials. J Clin Epidemiol 2014;67:1150–56 doi:10.1016/j.jclinepi.2014.04.010 pmid:25042688
    CrossRefPubMed
  29. 29.↵
    1. Bacchus E,
    2. Kate MP,
    3. Benomar A, et al
    . Inter-rater reliability of the simplified modified Rankin scale as an outcome measure for treated cerebral aneurysm patients. Neurochirurgie 2022;68:488–92 doi:10.1016/j.neuchi.2022.04.003 pmid:35662528
    CrossRefPubMed
  30. 30.↵
    1. Darsaut TE,
    2. Keough MB,
    3. Boisseau W, et al
    . Middle Cerebral Artery Aneurysm Trial (MCAAT): a randomized care trial comparing surgical and endovascular management of MCA aneurysm patients. World Neurosurg 2022;160:e49–54 doi:10.1016/j.wneu.2021.12.083 pmid:34971833
    CrossRefPubMed
  31. 31.↵
    1. Huang MC,
    2. Baaj AA,
    3. Downes K, et al
    . Paradoxical trends in the management of unruptured cerebral aneurysms in the United States: analysis of nationwide database over a 10-year period. Stroke 2011;42:1730–35 doi:10.1161/STROKEAHA.110.603803 pmid:21493902
    Abstract/FREE Full Text
  32. 32.↵
    1. Andaluz N,
    2. Zuccarello M
    . Recent trends in the treatment of cerebral aneurysms: analysis of a nationwide inpatient database. J Neurosurg 2008;108:1163–69 doi:10.3171/JNS/2008/108/6/1163 pmid:18518722
    CrossRefPubMedWeb of Science
  33. 33.↵
    1. Macdonald RL
    . Editorial: clip or coil? Six years of follow-up in BRAT. J Neurosurg 2015;123:605–07 doi:10.3171/2014.11.JNS142261 pmid:26115466
    CrossRefPubMed
  34. 34.↵
    1. Iancu D,
    2. Collins J,
    3. Farzin B, et al
    . Recruitment in a pragmatic randomized trial on the management of unruptured intracranial aneurysms. World Neurosurg 2022;163:e413–19 doi:10.1016/j.wneu.2022.03.142 pmid:35395427
    CrossRefPubMed
PreviousNext
Back to top
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
T.E. Darsaut, J.M. Findlay, M.W. Bojanowski, C. Chalaala, D. Iancu, D. Roy, A. Weill, W. Boisseau, A. Diouf, E. Magro, M. Kotowski, M.B. Keough, L. Estrade, N. Bricout, J.-P. Lejeune, M.M.C. Chow, C.J. O’Kelly, J.L. Rempel, R.A. Ashforth, H. Lesiuk, J. Sinclair, U.-E. Erdenebold, J.H. Wong, F. Scholtes, D. Martin, B. Otto, A. Bilocq, E. Truffer, K. Butcher, A.J. Fox, A.S. Arthur, L. Létourneau-Guillon, F. Guilbert, M. Chagnon, J. Zehr, B. Farzin, G. Gevry, J. Raymond
A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms
American Journal of Neuroradiology May 2023, DOI: 10.3174/ajnr.A7865

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
A Pragmatic Randomized Trial Comparing Surgical Clipping and Endovascular Treatment of Unruptured Intracranial Aneurysms
T.E. Darsaut, J.M. Findlay, M.W. Bojanowski, C. Chalaala, D. Iancu, D. Roy, A. Weill, W. Boisseau, A. Diouf, E. Magro, M. Kotowski, M.B. Keough, L. Estrade, N. Bricout, J.-P. Lejeune, M.M.C. Chow, C.J. O’Kelly, J.L. Rempel, R.A. Ashforth, H. Lesiuk, J. Sinclair, U.-E. Erdenebold, J.H. Wong, F. Scholtes, D. Martin, B. Otto, A. Bilocq, E. Truffer, K. Butcher, A.J. Fox, A.S. Arthur, L. Létourneau-Guillon, F. Guilbert, M. Chagnon, J. Zehr, B. Farzin, G. Gevry, J. Raymond
American Journal of Neuroradiology May 2023, DOI: 10.3174/ajnr.A7865
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Supplemental
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • PubMed
  • Google Scholar

Cited By...

  • Optimizing Photon-Counting Detector CT for Imaging Intracranial Aneurysms
  • Management of wide-neck aneurysms in 2024: how does one make the best treatment decision when there are so many good options?
  • Response to: Correspondence on "Cerebral aneurysms: Germany-wide real-world outcome data of endovascular or neurosurgical treatment from 2007 to 2019" by Cole
  • Appreciation and Concerns Regarding the Published Study "CURES"
  • Reply:
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • Rescue Reentry in Carotid Near-Occlusion
  • Contour Neurovascular System: Five Year Follow Up
  • Effect of SARS-CoV2 on Endovascular Thrombectomy
Show more Neurointervention

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire