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Research ArticleUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection

Diffusion- and Tractography-Based Characterization of Tissue Damage Within and Surrounding Paramagnetic Rim Lesions in Multiple Sclerosis

Maryam Mohebbi, Jack A. Reeves, Dejan Jakimovski, Alexander Bartnik, Niels Bergsland, Fahad Salman, Ferdinand Schweser, Bianca Weinstock-Guttman, Robert Zivadinov and Michael G. Dwyer
American Journal of Neuroradiology March 2025, 46 (3) 611-619; DOI: https://doi.org/10.3174/ajnr.A8524
Maryam Mohebbi
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
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Jack A. Reeves
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
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Dejan Jakimovski
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
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  • ORCID record for Dejan Jakimovski
Alexander Bartnik
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
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Niels Bergsland
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
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Fahad Salman
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
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Ferdinand Schweser
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
bCenter for Biomedical Imaging at the Clinical Translational Science Institute (F.Schweser, R.Z.), University at Buffalo, State University of New York, Buffalo, New York
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Bianca Weinstock-Guttman
cJacobs Neurological Institute (B.W.-G.), Buffalo, New York
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Robert Zivadinov
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
bCenter for Biomedical Imaging at the Clinical Translational Science Institute (F.Schweser, R.Z.), University at Buffalo, State University of New York, Buffalo, New York
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Michael G. Dwyer
aFrom the Buffalo Neuroimaging Analysis Center (M.M., J.A.R., D.J., A.B., N.B., F.Salman, F.Schweser, R.Z., M.G.D.), Department of Neurology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, State University of New York, Buffalo, New York
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References

  1. 1.↵
    1. Nylander A,
    2. Hafler DA
    . Multiple sclerosis. J Clin Invest 2012;122:1180–88 doi:10.1172/JCI58649 pmid:22466660
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Compston A,
    2. Coles A
    . Multiple sclerosis. Lancet 2008;372:1502–17 doi:10.1016/S0140-6736(08)61620-7 pmid:18970977
    CrossRefPubMedWeb of Science
  3. 3.↵
    1. Frohman EM,
    2. Racke MK,
    3. Raine CS
    . Multiple sclerosis—the plaque and its pathogenesis. N Engl J Med 2006;354:942–55 doi:10.1056/NEJMra052130 pmid:16510748
    CrossRefPubMedWeb of Science
  4. 4.↵
    1. Kuhlmann T,
    2. Ludwin S,
    3. Prat A, et al
    . An updated histological classification system for multiple sclerosis lesions. Acta Neuropathol 2017;133:13–24 doi:10.1007/s00401-016-1653-y
    CrossRefPubMed
  5. 5.↵
    1. Calvi A,
    2. Haider L,
    3. Prados F, et al
    . In vivo imaging of chronic active lesions in multiple sclerosis. Mult Scler 2022;28:683–90 doi:10.1177/1352458520958589 pmid:32965168
    CrossRefPubMed
  6. 6.↵
    1. Siger M
    . Magnetic resonance imaging in primary progressive multiple sclerosis patients: review. Clin Neuroradiol 2022;32:625–41 doi:10.1007/s00062-022-01144-3 pmid:35258820
    CrossRefPubMed
  7. 7.↵
    1. Filippi M,
    2. Preziosa P,
    3. Barkhof F, et al
    . Diagnosis of progressive multiple sclerosis from the imaging perspective: a review. JAMA Neurol 2021;78:351–64 doi:10.1001/jamaneurol.2020.4689 pmid:33315071
    CrossRefPubMed
  8. 8.↵
    1. Bagnato F,
    2. Sati P,
    3. Hemond CC, et al
    . Imaging chronic active lesions in multiple sclerosis: a consensus statement. Brain 2024;147:213–33 doi:10.1093/brain/awae013
    CrossRefPubMed
  9. 9.↵
    1. Absinta M,
    2. Sati P,
    3. Masuzzo F, et al
    . Association of chronic active multiple sclerosis lesions with disability in vivo. JAMA Neurol 2019;76:1474–83 doi:10.1001/jamaneurol.2019.2399 pmid:31403674
    CrossRefPubMed
  10. 10.↵
    1. Ng Kee Kwong KC,
    2. Mollison D,
    3. Meijboom R, et al
    . The prevalence of paramagnetic rim lesions in multiple sclerosis: a systematic review and meta-analysis. PLoS One 2021;16:e0256845 doi:10.1371/journal.pone.0256845
    CrossRefPubMed
  11. 11.↵
    1. Reeves JA,
    2. Weinstock Z,
    3. Zivadinov R, et al
    . Paramagnetic rim lesions are associated with greater incidence of relapse and worse cognitive recovery following relapse. Mult Scler 2023;29:1033–38 doi:10.1177/13524585231169466 pmid:37161349
    CrossRefPubMed
  12. 12.↵
    1. Dal-Bianco A,
    2. Grabner G,
    3. Kronnerwetter C, et al
    . Slow expansion of multiple sclerosis iron rim lesions: pathology and 7 T magnetic resonance imaging. Acta Neuropathol 2017;133:25–42 doi:10.1007/s00401-016-1636-z
    CrossRefPubMed
  13. 13.↵
    1. Jakimovski D,
    2. Gandhi S,
    3. Paunkoski I, et al
    . Hypertension and heart disease are associated with development of brain atrophy in multiple sclerosis: a 5‐year longitudinal study. Euro J Neuro 2019;26:87 doi:10.1111/ene.13769 pmid:30103277
    CrossRefPubMed
  14. 14.↵
    1. Zhou D,
    2. Liu T,
    3. Spincemaille P, et al
    . Background field removal by solving the Laplacian boundary value problem. NMR Biomed 2014;27:312–19 doi:10.1002/nbm.3064 pmid:24395595
    CrossRefPubMed
  15. 15.↵
    1. Schweser F,
    2. Deistung A,
    3. Sommer K, et al
    . Toward online reconstruction of quantitative susceptibility maps: superfast dipole inversion. Magn Reson Med 2013;69:1582–94 pmid:22791625
    CrossRefPubMed
  16. 16.↵
    1. Zivadinov R,
    2. Rudick RA,
    3. De Masi R, et al
    . Effects of IV methylprednisolone on brain atrophy in relapsing-remitting MS. Neurology 2001;57:1239–47 doi:10.1212/wnl.57.7.1239 pmid:11591843
    Abstract/FREE Full Text
  17. 17.↵
    1. Reeves JA,
    2. Mohebbi M,
    3. Zivadinov R, et al
    . Reliability of paramagnetic rim lesion classification on quantitative susceptibility mapping (QSM) in people with multiple sclerosis: single-site experience and systematic review. Mult Scler Relat Disord 2023;79:104968 doi:10.1016/j.msard.2023.104968
    CrossRefPubMed
  18. 18.↵
    1. Schilling KG,
    2. Blaber J,
    3. Hansen C, et al
    . Distortion correction of diffusion weighted MRI without reverse phase-encoding scans or field-maps. PLoS ONE 2020;15:e0236418 doi:10.1371/journal.pone.0236418 pmid:32735601
    CrossRefPubMed
  19. 19.↵
    1. Schilling KG,
    2. Blaber J,
    3. Huo Y, et al
    . Synthesized b0 for diffusion distortion correction (Synb0-DisCo). Magn Reson Imaging 2019;64:62–70 doi:10.1016/j.MRI.2019.05.008
    CrossRefPubMed
  20. 20.↵
    1. Smith SM,
    2. Jenkinson M,
    3. Woolrich MW, et al
    . Advances in functional and structural MR image analysis and implementation as FSL. NeuroImage 2004;23 Suppl 1:S208–19 doi:10.1016/j.neuroimage.2004.07.051
    CrossRefPubMed
  21. 21.↵
    1. Andersson JLR,
    2. Skare S,
    3. Ashburner J
    . How to correct susceptibility distortions in spin-echo echo-planar images: application to diffusion tensor imaging. NeuroImage 2003;20:870–88 doi:10.1016/S1053-8119(03)00336-7
    CrossRefPubMedWeb of Science
  22. 22.↵
    1. Andersson JLR,
    2. Sotiropoulos SN
    . An integrated approach to correction for off-resonance effects and subject movement in diffusion MR imaging. NeuroImage 2016;125:1063–78 doi:10.1016/j.neuroimage.2015.10.019 pmid:26481672
    CrossRefPubMed
  23. 23.↵
    1. Yeh F-C,
    2. Wedeen VJ,
    3. Tseng WYI
    . Generalized q-sampling imaging. IEEE Trans Med Imaging 2010;29:1626–35 doi:10.1109/TMI.2010.2045126 pmid:20304721
    CrossRefPubMedWeb of Science
  24. 24.↵
    1. Detobel J
    . Microstructural Analysis of Paramagnetic Rim Lesions in Multiple Sclerosis Using Diffusion Weighted Magnetic Resonance Imaging. Master’s thesis. Ecole Polytechnique de Louvain, Université Catholique de Louvain; 2022. http://hdl.handle.net/2078.1/thesis:37900
  25. 25.↵
    1. Shi Z,
    2. Pan Y,
    3. Yan Z, et al
    . Microstructural alterations in different types of lesions and their perilesional white matter in relapsing-remitting multiple sclerosis based on diffusion kurtosis imaging. Mult Scler Relat Disord 2023;71:104572 doi:10.1016/j.msard.2023.104572 pmid:36821979
    CrossRefPubMed
  26. 26.↵
    1. Hu H,
    2. Ye L,
    3. Ding S, et al
    . The heterogeneity of tissue destruction between iron rim lesions and non-iron rim lesions in multiple sclerosis: a diffusion MRI study. Mult Scler Relat Disord 2022;66:104070 doi:10.1016/j.msard.2022.104070 pmid:35914471
    CrossRefPubMed
  27. 27.↵
    1. Yeh FC,
    2. Verstynen TD,
    3. Wang Y, et al
    . Deterministic diffusion fiber tracking improved by quantitative anisotropy. PLoS ONE 2013;8:e80713 doi:10.1371/journal.pone.0080713 pmid:24348913
    CrossRefPubMed
  28. 28.↵
    1. Yeh F,
    2. Liu L,
    3. Hitchens TK, et al
    . Mapping immune cell infiltration using restricted diffusion MRI. Magn Reson Med 2017;77:603–12 doi:10.1002/mrm.26143
    CrossRefPubMed
  29. 29.↵
    1. Maggi P,
    2. Kuhle J,
    3. Schädelin S, et al
    . Chronic white matter inflammation and serum neurofilament levels in multiple sclerosis. Neurology 2021;97:e543–53 doi:10.1212/WNL.0000000000012326 pmid:34088875
    Abstract/FREE Full Text
  30. 30.↵
    1. Zhang J,
    2. Tao R,
    3. Liu C, et al
    . Possible effects of iron deposition on the measurement of DTI metrics in deep gray matter nuclei: an in vitro and in vivo study. Neuroscience Letters 2013;551:47–52 doi:10.1016/j.neulet.2013.07.003
    CrossRefPubMed
  31. 31.↵
    1. Yeh FC,
    2. Zaydan IM,
    3. Suski VR, et al
    . Differential tractography as a track-based biomarker for neuronal injury. NeuroImage 2019;202:116131 doi:10.1016/j.neuroimage.2019.116131
    CrossRefPubMed
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Maryam Mohebbi, Jack A. Reeves, Dejan Jakimovski, Alexander Bartnik, Niels Bergsland, Fahad Salman, Ferdinand Schweser, Bianca Weinstock-Guttman, Robert Zivadinov, Michael G. Dwyer
Diffusion- and Tractography-Based Characterization of Tissue Damage Within and Surrounding Paramagnetic Rim Lesions in Multiple Sclerosis
American Journal of Neuroradiology Mar 2025, 46 (3) 611-619; DOI: 10.3174/ajnr.A8524

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Tissue Damage Characterization in MS Using DWI
Maryam Mohebbi, Jack A. Reeves, Dejan Jakimovski, Alexander Bartnik, Niels Bergsland, Fahad Salman, Ferdinand Schweser, Bianca Weinstock-Guttman, Robert Zivadinov, Michael G. Dwyer
American Journal of Neuroradiology Mar 2025, 46 (3) 611-619; DOI: 10.3174/ajnr.A8524
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