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Research ArticleUltra-High-Field MRI/Imaging of Epilepsy/Demyelinating Diseases/Inflammation/Infection

Structural Brain MR Imaging Alterations in Patients with Systemic Lupus Erythematosus with and without Neuropsychiatric Events

Sebastiano Vacca, Michele Porcu, Matteo Piga, Lorenzo Mannelli, Elisabetta Chessa, Jasjit S. Suri, Antonella Balestrieri, Alberto Cauli and Luca Saba
American Journal of Neuroradiology June 2024, 45 (6) 802-808; DOI: https://doi.org/10.3174/ajnr.A8200
Sebastiano Vacca
aFrom the School of Medicine and Surgery (S.V.), University of Cagliari, Cagliari, Italy
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  • ORCID record for Sebastiano Vacca
Michele Porcu
bDepartment of Radiology (M. Piga, A.B., L.S.), Azienda Ospedaliero-Universitaria, Cagliari, Italy
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  • ORCID record for Michele Porcu
Matteo Piga
cDepartment of Medical Science and Public Health (M. Porcu, A.B., A.C.), University of Calgiari, Cagliari, Italy
dRheumatology Unit (M. Piga, E.C., A.C.), Azienda Ospedaliero Universitaria di Cagliari, Monserrato, Italy
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Lorenzo Mannelli
eInstitute for Hospitalization and Healthcare (L.M.), SDN, Napoli, Italy
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Elisabetta Chessa
dRheumatology Unit (M. Piga, E.C., A.C.), Azienda Ospedaliero Universitaria di Cagliari, Monserrato, Italy
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Jasjit S. Suri
fStroke Monitoring and Diagnostic Division (J.S.S.), AtheroPoint, Roseville, California
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  • ORCID record for Jasjit S. Suri
Antonella Balestrieri
bDepartment of Radiology (M. Piga, A.B., L.S.), Azienda Ospedaliero-Universitaria, Cagliari, Italy
cDepartment of Medical Science and Public Health (M. Porcu, A.B., A.C.), University of Calgiari, Cagliari, Italy
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  • ORCID record for Antonella Balestrieri
Alberto Cauli
cDepartment of Medical Science and Public Health (M. Porcu, A.B., A.C.), University of Calgiari, Cagliari, Italy
dRheumatology Unit (M. Piga, E.C., A.C.), Azienda Ospedaliero Universitaria di Cagliari, Monserrato, Italy
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Luca Saba
bDepartment of Radiology (M. Piga, A.B., L.S.), Azienda Ospedaliero-Universitaria, Cagliari, Italy
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    FIG 1.

    Wilcoxon rank-sum test results combining multimodal MR brain imaging and machine learning to unravel neurocognitive function in non-NPSLE for volumetric differences between patients with SLE and NPSLE, SLEDAI-2K higher or lower than 4, and SLICC-DI higher or lower than 1. PHG indicates parahippocampal gyrus; OpiFG, opercular part of the inferior frontal gyrus; MPoG, medial precentral gyrus; CO, central operculum of the insula; SMG, supramarginal gyrus.

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    FIG 2.

    Tissue segmentation of a patient with NPSLE and one with SLE, respectively, first and second row. Each color represents a different brain structure, such as gray and white matter and CSF.

  • FIG 3.
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    FIG 3.

    Structure segmentation of a patient with NPSLE and one with SLE, respectively, first and second row. Each color represents a different brain region.

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American Journal of Neuroradiology: 45 (6)
American Journal of Neuroradiology
Vol. 45, Issue 6
1 Jun 2024
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Cite this article
Sebastiano Vacca, Michele Porcu, Matteo Piga, Lorenzo Mannelli, Elisabetta Chessa, Jasjit S. Suri, Antonella Balestrieri, Alberto Cauli, Luca Saba
Structural Brain MR Imaging Alterations in Patients with Systemic Lupus Erythematosus with and without Neuropsychiatric Events
American Journal of Neuroradiology Jun 2024, 45 (6) 802-808; DOI: 10.3174/ajnr.A8200

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Brain MR Imaging in Systemic Lupus Erythematosus
Sebastiano Vacca, Michele Porcu, Matteo Piga, Lorenzo Mannelli, Elisabetta Chessa, Jasjit S. Suri, Antonella Balestrieri, Alberto Cauli, Luca Saba
American Journal of Neuroradiology Jun 2024, 45 (6) 802-808; DOI: 10.3174/ajnr.A8200
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