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AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleNeurovascular/Stroke Imaging

Effect of Clot Burden Score on Safety and Efficacy of Intravenous Alteplase Prior to Mechanical Thrombectomy in Acute Ischemic Stroke: A Subgroup Analysis of a Randomized Phase 3 Trial

Zifu Li, Yu Zhou, Xiaoxi Zhang, Lei Zhang, Yongwei Zhang, Pengfei Xing, Yongxin Zhang, Qinghai Huang, Qiang Li, Qiao Zuo, Xiaofei Ye, Jianmin Liu, Pengfei Yang and on behalf of DIRECT-MT Investigators
American Journal of Neuroradiology March 2024, 45 (3) 296-301; DOI: https://doi.org/10.3174/ajnr.A8134
Zifu Li
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Yu Zhou
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Xiaoxi Zhang
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Lei Zhang
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Yongwei Zhang
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Pengfei Xing
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Yongxin Zhang
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Qinghai Huang
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Qiang Li
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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  • ORCID record for Qiang Li
Qiao Zuo
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Xiaofei Ye
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Jianmin Liu
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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Pengfei Yang
aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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aFrom the Neurovascular Center, Changhai Hospital, Naval Medical University, Shanghai, China
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    FIG 1.

    Treatment effect for mRS distribution shift on 90 days in trichotomized subgroups.

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    FIG 2.

    Treatment effect for mRS distribution shift on 90 days by treatment group in trichotomized subgroups.

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    FIG 3.

    Safety outcomes by treatment group in trichotomized subgroups.

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American Journal of Neuroradiology: 45 (3)
American Journal of Neuroradiology
Vol. 45, Issue 3
1 Mar 2024
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Effect of Clot Burden Score on Safety and Efficacy of Intravenous Alteplase Prior to Mechanical Thrombectomy in Acute Ischemic Stroke: A Subgroup Analysis of a Randomized Phase 3 Trial
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Zifu Li, Yu Zhou, Xiaoxi Zhang, Lei Zhang, Yongwei Zhang, Pengfei Xing, Yongxin Zhang, Qinghai Huang, Qiang Li, Qiao Zuo, Xiaofei Ye, Jianmin Liu, Pengfei Yang, on behalf of DIRECT-MT Investigators
Effect of Clot Burden Score on Safety and Efficacy of Intravenous Alteplase Prior to Mechanical Thrombectomy in Acute Ischemic Stroke: A Subgroup Analysis of a Randomized Phase 3 Trial
American Journal of Neuroradiology Mar 2024, 45 (3) 296-301; DOI: 10.3174/ajnr.A8134

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Clot Burden Score and IV Alteplase Efficacy
Zifu Li, Yu Zhou, Xiaoxi Zhang, Lei Zhang, Yongwei Zhang, Pengfei Xing, Yongxin Zhang, Qinghai Huang, Qiang Li, Qiao Zuo, Xiaofei Ye, Jianmin Liu, Pengfei Yang, on behalf of DIRECT-MT Investigators
American Journal of Neuroradiology Mar 2024, 45 (3) 296-301; DOI: 10.3174/ajnr.A8134
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