Skip to main content
Advertisement

Main menu

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home

User menu

  • Alerts
  • Log in

Search

  • Advanced search
American Journal of Neuroradiology
American Journal of Neuroradiology

American Journal of Neuroradiology

ASHNR American Society of Functional Neuroradiology ASHNR American Society of Pediatric Neuroradiology ASSR
  • Alerts
  • Log in

Advanced Search

  • Home
  • Content
    • Current Issue
    • Accepted Manuscripts
    • Article Preview
    • Past Issue Archive
    • Video Articles
    • AJNR Case Collection
    • Case of the Week Archive
    • Case of the Month Archive
    • Classic Case Archive
  • Special Collections
    • AJNR Awards
    • Low-Field MRI
    • Alzheimer Disease
    • ASNR Foundation Special Collection
    • Photon-Counting CT
    • View All
  • Multimedia
    • AJNR Podcasts
    • AJNR SCANtastic
    • Trainee Corner
    • MRI Safety Corner
    • Imaging Protocols
  • For Authors
    • Submit a Manuscript
    • Submit a Video Article
    • Submit an eLetter to the Editor/Response
    • Manuscript Submission Guidelines
    • Statistical Tips
    • Fast Publishing of Accepted Manuscripts
    • Graphical Abstract Preparation
    • Imaging Protocol Submission
    • Author Policies
  • About Us
    • About AJNR
    • Editorial Board
    • Editorial Board Alumni
  • More
    • Become a Reviewer/Academy of Reviewers
    • Subscribers
    • Permissions
    • Alerts
    • Feedback
    • Advertisers
    • ASNR Home
  • Follow AJNR on Twitter
  • Visit AJNR on Facebook
  • Follow AJNR on Instagram
  • Join AJNR on LinkedIn
  • RSS Feeds

AJNR Awards, New Junior Editors, and more. Read the latest AJNR updates

Research ArticleHead and Neck Imaging

Imaging Features of Craniofacial Giant Cell Granulomas: A Large Retrospective Analysis from a Tertiary Care Center

R. Chanda, S.S. Regi, M. Kandagaddala, A. Irodi, M. Thomas and M. John
American Journal of Neuroradiology August 2022, 43 (8) 1190-1195; DOI: https://doi.org/10.3174/ajnr.A7568
R. Chanda
aFrom the Departments of Radiodiagnosis (R.C., S.S.R., M.K., A.I.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for R. Chanda
S.S. Regi
aFrom the Departments of Radiodiagnosis (R.C., S.S.R., M.K., A.I.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for S.S. Regi
M. Kandagaddala
aFrom the Departments of Radiodiagnosis (R.C., S.S.R., M.K., A.I.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Kandagaddala
A. Irodi
aFrom the Departments of Radiodiagnosis (R.C., S.S.R., M.K., A.I.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for A. Irodi
M. Thomas
bPathology (M.T.)
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. Thomas
M. John
cOtorhinolaryngology (M.J.), Christian Medical College, Vellore, India
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for M. John
  • Article
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF
Loading

References

  1. 1.↵
    1. Jaffe HL
    . Giant-cell reparative granuloma, traumatic bone cyst, and fibrous (fibro-osseous) dysplasia of the jawbones. Oral Surg Oral Med Oral Pathol 1953;6:159–75 doi:10.1016/0030-4220(53)90151-0 pmid:13026160
    CrossRefPubMedWeb of Science
  2. 2.↵
    1. Firminger H
    1. Ackerman LV,
    2. Spjut HJ
    . Giant cell reaction. In: Firminger H, ed. Atlas of Tumor Pathology: Tumors of Bone and Cartilage, fascicle 5, series 2. Washington, DC: American Registry of Pathology 1962;293–314
  3. 3.↵
    1. Barnes L,
    2. Eveson JW,
    3. Reichart P
    , et al. eds. Pathology and Genetics of Head and Neck Tumours. World Health Organization/International Agency for Research on Cancer; 2005
  4. 4.↵
    1. El-Naggar AK,
    2. Chan JK,
    3. Grandis JR
    , et al. eds. WHO Classification of Head and Neck Tumours. Vol 9. 4th ed. World Health Organization/International Agency for Research on Cancer; 2017
  5. 5.↵
    1. Nackos JS,
    2. Wiggins RH,
    3. Harnsberger HR
    . CT and MR imaging of giant cell granuloma of the craniofacial bones. AJNR Am J Neuroradiol 2006;27:1651–53 pmid:16971606
    PubMedWeb of Science
  6. 6.↵
    1. Fechner RE,
    2. Fitz-Hugh GS,
    3. Pope TL
    . Extraordinary growth of giant cell reparative granuloma during pregnancy. Arch Otolaryngol Chic Otolaryngol 1984;110:116–19 doi:10.1001/archotol.1984.00800280050015 pmid:6696681
    CrossRefPubMed
  7. 7.↵
    1. Nielsen GP,
    2. Rosenberg AE
    . Diagnostic pathology: Bone. Elsevier Health Sciences; 2021
  8. 8.↵
    1. Fletcher C
    . Diagnostic Histopathology of Tumors. 2 Volume Set. 5th ed. Elsevier; 2019
  9. 9.↵
    1. Oliveira AM,
    2. Perez-Atayde AR,
    3. Inwards CY, et al
    . USP6 and CDH11 oncogenes identify the neoplastic cell in primary aneurysmal bone cysts and are absent in so-called secondary aneurysmal bone cysts. Am J Pathol 2004;165:1773–80 doi:10.1016/S0002-9440(10)63432-3 pmid:15509545
    CrossRefPubMedWeb of Science
  10. 10.↵
    1. Presneau N,
    2. Baumhoer D,
    3. Behjati S, et al
    . Diagnostic value of H3F3A mutations in giant cell tumour of bone compared to osteoclast‐rich mimics. J Pathol Clin Res 2015;1:113–23 doi:10.1002/cjp2.13 pmid:27499898
    CrossRefPubMed
  11. 11.↵
    1. Scotto di Carlo F,
    2. Divisato G,
    3. Iacoangeli M, et al
    . The identification of H3F3A mutation in giant cell tumour of the clivus and the histological diagnostic algorithm of other clival lesions permit the differential diagnosis in this location. BMC Cancer 2018;18:358 doi:10.1186/s12885-018-4291-z pmid:29609578
    CrossRefPubMed
  12. 12.↵
    1. Nagar SR,
    2. Bansal S,
    3. Jashnani K, et al
    . A comparative analysis of p63 expression in giant cell tumour (GCT), central giant cell granuloma (CGCG) and peripheral giant cell granuloma (PGCG). Head and Neck Pathol 2020;14:733–41 doi:10.1007/s12105-019-01118-x pmid:31873936
    CrossRefPubMed
  13. 13.↵
    1. Ung F,
    2. Li KK,
    3. Keith DA
    , et al. Giant cell reparative granuloma of the temporal bone: case report and review of the literature. Otolaryngol Head Neck Surg 1998;118:525–29 doi:10.1177/019459989811800415 pmid:9560106
    CrossRefPubMed
  14. 14.↵
    1. Regezi JA
    . Odontogenic cysts, odontogenic tumors, fibro-osseous, and giant cell lesions of the jaws. Mod Pathol 2002;15:331–41 doi:10.1038/modpathol.3880527 pmid:11904346
    CrossRefPubMed
  15. 15.↵
    1. Murphey MD,
    2. Nomikos GC,
    3. Flemming DJ, et al
    . From the archives of AFIP: imaging of giant cell tumor and giant cell reparative granuloma of bone—radiologic-pathologic correlation. Radiographics 2001;21:1283–309 doi:10.1148/radiographics.21.5.g01se251283 pmid:11553835
    CrossRefPubMedWeb of Science
  16. 16.↵
    1. Rao A,
    2. Sharma C,
    3. Parampalli R
    . Role of diffusion-weighted MRI in differentiating benign from malignant bone tumors. BJR Open 2019;1:20180048 doi:10.1259/bjro.20180048 pmid:33178932
    CrossRefPubMed
  17. 17.↵
    1. Nouh MR,
    2. Doweidar A,
    3. Khalil AM
    . Apparent diffusion coefficient (ADC): a potential in vivo biological surrogate of the incidentally discovered bone lesions at 3T MRI. Eur J Radiol Open 2021;8:100386 doi:10.1016/j.ejro.2021.100386 pmid:34877369
    CrossRefPubMed
  18. 18.↵
    1. Ashikyan O,
    2. Chalian M,
    3. Moore D, et al
    . Evaluation of giant cell tumors by diffusion weighted imaging-fractional ADC analysis. Skeletal Radiol 2019;48:1765–73 doi:10.1007/s00256-019-03219-8 pmid:31001688
    CrossRefPubMed
  19. 19.↵
    1. Shrestha S,
    2. Zhang J,
    3. Yan J, et al
    . Radiological features of central giant cell granuloma: comparative study of 7 cases and literature review. Dentomaxillofac Radiol 2021;50:20200429 doi:10.1259/dmfr.20200429 pmid:33881907
    CrossRefPubMed
  20. 20.↵
    1. Jamil OA,
    2. Lechpammer M,
    3. Prasad S, et al
    . Giant cell reparative granuloma of the sphenoid: case report and review of the literature. Surg Neurol Int 2012;3:140 doi:10.4103/2152-7806.103878 pmid:23230521
    CrossRefPubMed
  21. 21.↵
    1. Aralasmak A,
    2. Aygun N,
    3. Westra WH, et al
    . Giant cell reparative granuloma of the sphenoid bone. AJNR Am J Neuroradiol 2006;27:1675–77 pmid:16971612
    PubMed
  22. 22.↵
    1. Borges BB,
    2. Fornazieri MA,
    3. Correia de Araújo Bezerra AP, et al
    . Giant cell bone lesions in the craniofacial region: a diagnostic and therapeutic challenge. Int Forum Allergy Rhinol 2012;2:501–06 doi:10.1002/alr.21050 pmid:22566483
    CrossRefPubMed
PreviousNext
Back to top

In this issue

American Journal of Neuroradiology: 43 (8)
American Journal of Neuroradiology
Vol. 43, Issue 8
1 Aug 2022
  • Table of Contents
  • Index by author
  • Complete Issue (PDF)
Advertisement
Print
Download PDF
Email Article

Thank you for your interest in spreading the word on American Journal of Neuroradiology.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Imaging Features of Craniofacial Giant Cell Granulomas: A Large Retrospective Analysis from a Tertiary Care Center
(Your Name) has sent you a message from American Journal of Neuroradiology
(Your Name) thought you would like to see the American Journal of Neuroradiology web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Cite this article
R. Chanda, S.S. Regi, M. Kandagaddala, A. Irodi, M. Thomas, M. John
Imaging Features of Craniofacial Giant Cell Granulomas: A Large Retrospective Analysis from a Tertiary Care Center
American Journal of Neuroradiology Aug 2022, 43 (8) 1190-1195; DOI: 10.3174/ajnr.A7568

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
0 Responses
Respond to this article
Share
Bookmark this article
Imaging Craniofacial Giant Cell Granulomas
R. Chanda, S.S. Regi, M. Kandagaddala, A. Irodi, M. Thomas, M. John
American Journal of Neuroradiology Aug 2022, 43 (8) 1190-1195; DOI: 10.3174/ajnr.A7568
del.icio.us logo Twitter logo Facebook logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One
Purchase

Jump to section

  • Article
    • Abstract
    • ABBREVIATIONS:
    • MATERIALS AND METHODS
    • RESULTS
    • DISCUSSION
    • CONCLUSIONS
    • Acknowledgment
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • Responses
  • References
  • PDF

Related Articles

  • No related articles found.
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Crossref
  • Google Scholar

This article has not yet been cited by articles in journals that are participating in Crossref Cited-by Linking.

More in this TOC Section

  • MRI of the Parasellar Ligaments
  • ASL Sensitivity for Head and Neck Paraganglioma
  • Post SRS Peritumoral Hyperintense Signal of VSs
Show more Head and Neck Imaging

Similar Articles

Advertisement

Indexed Content

  • Current Issue
  • Accepted Manuscripts
  • Article Preview
  • Past Issues
  • Editorials
  • Editor's Choice
  • Fellows' Journal Club
  • Letters to the Editor
  • Video Articles

Cases

  • Case Collection
  • Archive - Case of the Week
  • Archive - Case of the Month
  • Archive - Classic Case

More from AJNR

  • Trainee Corner
  • Imaging Protocols
  • MRI Safety Corner
  • Book Reviews

Multimedia

  • AJNR Podcasts
  • AJNR Scantastics

Resources

  • Turnaround Time
  • Submit a Manuscript
  • Submit a Video Article
  • Submit an eLetter to the Editor/Response
  • Manuscript Submission Guidelines
  • Statistical Tips
  • Fast Publishing of Accepted Manuscripts
  • Graphical Abstract Preparation
  • Imaging Protocol Submission
  • Evidence-Based Medicine Level Guide
  • Publishing Checklists
  • Author Policies
  • Become a Reviewer/Academy of Reviewers
  • News and Updates

About Us

  • About AJNR
  • Editorial Board
  • Editorial Board Alumni
  • Alerts
  • Permissions
  • Not an AJNR Subscriber? Join Now
  • Advertise with Us
  • Librarian Resources
  • Feedback
  • Terms and Conditions
  • AJNR Editorial Board Alumni

American Society of Neuroradiology

  • Not an ASNR Member? Join Now

© 2025 by the American Society of Neuroradiology All rights, including for text and data mining, AI training, and similar technologies, are reserved.
Print ISSN: 0195-6108 Online ISSN: 1936-959X

Powered by HighWire