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Research ArticleExtracranial Vascular

Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events

L. Saba, H. Chen, R. Cau, G.D. Rubeis, G. Zhu, F. Pisu, B. Jang, G. Lanzino, J.S. Suri, Y. Qi and M. Wintermark
American Journal of Neuroradiology February 2022, 43 (2) 272-279; DOI: https://doi.org/10.3174/ajnr.A7401
L. Saba
aFrom the Department of Radiology (L.S., R.C., F.P.), Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy
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  • ORCID record for L. Saba
H. Chen
bDepartment of Radiology (H.C., G.Z., B.J., M.W.), Division of Neuroradiology, Stanford University Hospital, Stanford, California
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R. Cau
aFrom the Department of Radiology (L.S., R.C., F.P.), Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy
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G.D. Rubeis
cDepartment of Radiology, UOC of Diagnostic and Interventional Neuroradiology (G.D.R.), San Camillo-Forlanini Hospital, Rome, Italy
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G. Zhu
bDepartment of Radiology (H.C., G.Z., B.J., M.W.), Division of Neuroradiology, Stanford University Hospital, Stanford, California
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F. Pisu
aFrom the Department of Radiology (L.S., R.C., F.P.), Azienda Ospedaliero Universitaria di Cagliari, Cagliari, Italy
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B. Jang
bDepartment of Radiology (H.C., G.Z., B.J., M.W.), Division of Neuroradiology, Stanford University Hospital, Stanford, California
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G. Lanzino
dDepartment of Neurologic Surgery (G.L.), Mayo Clinic, Rochester, Minnesota
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J.S. Suri
eStroke Monitoring and Diagnostic Division (J.S.S.), AtheroPoint, Roseville, California
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Y. Qi
fDepartment of Xuanwu Hospital (Y.Q.), Capital Medical University, Beijing, Chin
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M. Wintermark
bDepartment of Radiology (H.C., G.Z., B.J., M.W.), Division of Neuroradiology, Stanford University Hospital, Stanford, California
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Article Figures & Data

Figures

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  • FIG 1.
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    FIG 1.

    Scheme showing the different types of configurations with the corresponding CTA findings.

  • FIG 2.
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    FIG 2.

    Bar plots in symptomatic and asymptomatic subjects according to the plaque configuration for the total plaque count (A), the right side (B), and left side (C).

  • FIG 3.
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    FIG 3.

    Bar plots in symptomatic and asymptomatic subjects according to the plaque configuration for the total on the right (upper row) and left (lower row) sides for cardiovascular risk factors. CAD indicates coronary artery disease; Y, yes; N, no.

  • FIG 4.
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    FIG 4.

    The Pearson ρ correlogram shows the correlation test among the different demographic variables and the calcification types. Each box represents a correlation test, the blue values represent negative correlations, and the red values represent positive associations. CAD indicates coronary artery disease; L, left; R, right.

Tables

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    Table 1:

    Demographic and risk factors  

    SymptomsP Value
    NoYes
    Sex
     Female159299.5
     Male123209
    Age (mean value in years)69.1 (SD, 12)70.1 (SD, 13).68
    Hypertension
     No110177.25
     Yes172331
    Smoking status
     <2 years66143.26
     >2 years56105
     No160260
    CAD
     No231407.54
     Yes51101
    Diabetes
     No207383.54
     Yes75125
    Hyperlipidemia
     No101116<.001a
     Yes181392
    • Note:—CAD indicates coronary artery disease.

    • ↵a Significant.

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    Table 2:

    Crosstabulation between calcified plaque on the right and left sides

    Calcification Type on the Right SideCalcification Type on the Left SideTotal
    Type 1Type 2Type 3Type 4Type 5Type 6
    Type 12131519383261
    Type 220153965287
    Type 33940107192115241
    Type 466321171072
    Type 557261019976
    Type 6632584753
    Total28986248576446790
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American Journal of Neuroradiology: 43 (2)
American Journal of Neuroradiology
Vol. 43, Issue 2
1 Feb 2022
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Cite this article
L. Saba, H. Chen, R. Cau, G.D. Rubeis, G. Zhu, F. Pisu, B. Jang, G. Lanzino, J.S. Suri, Y. Qi, M. Wintermark
Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events
American Journal of Neuroradiology Feb 2022, 43 (2) 272-279; DOI: 10.3174/ajnr.A7401

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Impact Analysis of Different CT Configurations of Carotid Artery Plaque Calcifications on Cerebrovascular Events
L. Saba, H. Chen, R. Cau, G.D. Rubeis, G. Zhu, F. Pisu, B. Jang, G. Lanzino, J.S. Suri, Y. Qi, M. Wintermark
American Journal of Neuroradiology Feb 2022, 43 (2) 272-279; DOI: 10.3174/ajnr.A7401
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Cited By...

  • Cracking the Code of Calcification: How Presence and Burden among Intracranial Arteries Influence Stroke Incidence and Recurrence
  • MR Imaging of Carotid Artery Atherosclerosis: Updated Evidence on High-Risk Plaque Features and Emerging Trends
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More in this TOC Section

  • Proximal Vertebral Artery Variants and Embryology
  • High-Risk Plaque Features in Carotid MRI
  • Nonstenotic Carotid Plaques and Stroke Review
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