Article Figures & Data
Figures
- Fig 1.
QSM images (A and B) and selected regions of interest (C and D). CA indicates caudate nucleus; GP, globus pallidus; PU, putamen; RN, red nucleus; SN, substantia nigra; TH, thalamus.
- Fig 2.
R2* (top row) and QSM maps (bottom row) of 2 subjects, a 68-year-old control subject (A and C) and a 66-year-old patient with PD (B and D). Both the R2* and the QSM maps show higher paramagnetic susceptibility in the substantia nigra of the patient with PD than in the control (arrows).
- Fig 3.
Graphs of the ROC curves for discriminating patients with PD and the controls. The Az value was 0.91 for QSMaverage, 0.90 for QSMmaximum, 0.69 for R2*average, and 0.71 for R2*maximum. Pair-wise comparisons showed that the Az for QSMaverage and QSMmaximum was significantly larger than that for R2*average and R2*maximum (P < .05).
Tables
Patients with PD (n = 21) Controls (n = 21) P Sex (M/F) 9:12 9:12 1.00 Age (yr) (mean) 72.0 ± 7.5 69.7 ± 8.6 .54 Onset (yr) (mean) 69.0 ± 8.3 Disease duration (mo) (mean) 32.7 ± 27.1 H & Y stage (median) (range) 2 (1–3) Note:—H & Y stage indicates Hoehn and Yahr stage.
QSM (ppm) R2* Value (1/SE) Patients with PD Controls P Value Patients with PD Controls P Value Substantia nigra 0.224 ± 0.014a 0.199 ± 0.014 .01 × 10−3 30.1 ± 1.5b 29.0 ± 2.0 .01 Red nucleus 0.188 ± 0.021 0.195 ± 0.019 .15 27.0 ± 1.7 27.8 ± 2.2 .08 Globus pallidus 0.200 ± 0.014 0.205 ± 0.029 .82 29.7 ± 1.8 29.5 ± 2.1 .36 Head of caudate 0.166 ± 0.013 0.166 ± 0.013 .97 25.2 ± 1.4 24.6 ± 1.7 .19 Putamen 0.168 ± 0.013 0.170 ± 0.009 .17 26.4 ± 0.9 26.7 ± 1.6 .44 Thalamus 0.127 ± 0.059 0.126 ± 0.007 .53 22.4 ± 1.0 22.8 ± 1.2 .25 Mean No. of Sections Mean Volume (mm3) Patients with PD Controls Patients with PD Controls P Value Substantia nigra 9.6 9.7 598.2 ± 88.0 612.5 ± 66.3 .59 Red nucleus 4.8 4.7 187.9 ± 15.3 189.3 ± 16.6 .87 Globus pallidus 19.0 19.1 2734.7 ± 263.0 2667.1 ± 241.6 .54 Head of caudate 14.9 14.8 1529.9 ± 115.7 1564.6 ± 121.5 .47 Putamen 18.4 18.4 4964.5 ± 505.2 5127.1 ± 718.4 .62 Thalamus 15.2 15.1 1770.4 ± 89.7 1750.5 ± 118.4 .63
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