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Open Access

Endovascular Stroke Treatment Today

I.Q. Grunwald, A.K. Wakhloo, S. Walter, A.J. Molyneux, J.V. Byrne, S. Nagel, A.L. Kühn, M. Papadakis, K. Fassbender, J.S. Balami, M. Roffi, H. Sievert and A. Buchan
American Journal of Neuroradiology February 2011, 32 (2) 238-243; DOI: https://doi.org/10.3174/ajnr.A2346
I.Q. Grunwald
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A.K. Wakhloo
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S. Walter
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A.J. Molyneux
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J.V. Byrne
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S. Nagel
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A.L. Kühn
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M. Papadakis
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K. Fassbender
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J.S. Balami
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M. Roffi
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H. Sievert
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A. Buchan
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Abstract

SUMMARY: The purpose of this study was to review current treatment options in acute ischemic stroke, focusing on the latest advances in the field of mechanical recanalization. These devices recently made available for endovascular intracranial thrombectomy show great potential in acute stroke treatments. Compelling evidence of their recanalization efficacy comes from current mechanical embolectomy trials. In addition to allowing an extension of the therapeutic time window, mechanical recanalization devices can be used without adjuvant thrombolytic therapy, thus diminishing the intracranial bleeding risk. Therefore, these devices are particularly suitable in patients in whom thrombolytic therapy is contraindicated. IV and IA thrombolysis and bridging therapy are viable options in acute stroke treatment. Mechanical recanalization devices can potentially have a clinically relevant impact in the interventional treatment of stroke, but at the present time, a randomized study would be beneficial.

Abbreviations

CE
conformité européenne
DEDAS
Dose Escalation of Desmoteplase for Acute Ischemic Stroke
DIAS
Desmoteplase in Acute Ischemic Stroke
DWI
diffusion-weighted imaging
ECASS
European Cooperative Acute Stroke Studies
EPITHET
Echoplanar Imaging Thrombolytic Evaluation Trial
IA
intra-arterial
IMS
Interventional Management of Stroke
IV
intravenous
MCA
middle cerebral artery
mRS
modified Rankin Scale
NIHSS
National Institutes of Health Stroke Scale
PROACT
Prolyse in Acute Cerebral Thromboembolism
PWI
perfusion-weighted imaging
rtPA
recombinant tissue plasminogen activator
TIMI
Thrombolysis in Myocardial Infarction
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American Journal of Neuroradiology: 32 (2)
American Journal of Neuroradiology
Vol. 32, Issue 2
1 Feb 2011
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Cite this article
I.Q. Grunwald, A.K. Wakhloo, S. Walter, A.J. Molyneux, J.V. Byrne, S. Nagel, A.L. Kühn, M. Papadakis, K. Fassbender, J.S. Balami, M. Roffi, H. Sievert, A. Buchan
Endovascular Stroke Treatment Today
American Journal of Neuroradiology Feb 2011, 32 (2) 238-243; DOI: 10.3174/ajnr.A2346

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Endovascular Stroke Treatment Today
I.Q. Grunwald, A.K. Wakhloo, S. Walter, A.J. Molyneux, J.V. Byrne, S. Nagel, A.L. Kühn, M. Papadakis, K. Fassbender, J.S. Balami, M. Roffi, H. Sievert, A. Buchan
American Journal of Neuroradiology Feb 2011, 32 (2) 238-243; DOI: 10.3174/ajnr.A2346
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  • Article
    • Abstract
    • Abbreviations
    • IV Thrombolysis
    • Intra-Arterial Thrombolysis
    • Intravascular Thrombolysis Combined with Mechanical Thrombectomy
    • The Merci Retriever
    • The Phenox Clot Retriever
    • The Penumbra System
    • Stent Placement in Acute Stroke
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