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Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective

D. Jackson, S.R. Earnshaw, R. Farkouh and L. Schwamm
American Journal of Neuroradiology October 2010, 31 (9) 1669-1674; DOI: https://doi.org/10.3174/ajnr.A2138
D. Jackson
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S.R. Earnshaw
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R. Farkouh
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L. Schwamm
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    Fig 1.

    One-way sensitivity analysis: effect of parameter variation on the incremental cost per QALY for patient selection using penumbra-based CTP compared with CT. Dark-shaded bars represent the upper bound. Striped bars represent the lower bound. Baseline incremental cost / QALY = −$184,082.

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    Fig 2.

    Results of probabilistic sensitivity analysis: incremental cost-effectiveness scatterplot of patient selection using CTP versus CT for 90 days following primary stroke. Dotted line represents an incremental cost / QALY = $50,000. Points to right of the dotted the line are considered cost-effective. Gray dots represent simulations. The black dot represents the base-case result.

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    Table 1:

    Costs and outcomes associated with selecting patients for IV tPA treatment with CTP versus CT scanning base-case results

    Outcome (per patient)Usual CareCTP
    % of patients with ischemic stroke treated28.30%20.94%
    % of all patients with stroke treated24.62%18.22%
    % of all patients with stroke who receive CTP0.00%49.42%
    Favorable outcome (mRS, 0.1)39.44%40.03%
    mRS outcomes for patients with ischemic stroke
    % with 90-day mRS 018.41%18.23%
    % with 90-day mRS 121.03%21.80%
    % with 90-day mRS 212.56%11.96%
    % with 90-day mRS 313.14%13.27%
    % with 90-day mRS 415.75%16.13%
    % with 90-day mRS 57.13%6.78%
    % dead at 90 days11.98%11.83%
    Life-years0.21150.2119
    QALYs0.12410.1246
    Hospitalization costs (including SICH) (in US $)$11,400$11,358
    Novel diagnostic costs (in US $)$0$236
    Drug costs (in US $)$1,070$792
    Total costs (in US $)$12,470$12,386
    Incremental cost per life-year gained (in US $)–Cost-saving
    Incremental cost per QALY gained (in US $)–Cost-saving
    Incremental cost per major disability avoided (mRS, ≥3) (in US $)Cost-saving
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American Journal of Neuroradiology: 31 (9)
American Journal of Neuroradiology
Vol. 31, Issue 9
1 Oct 2010
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D. Jackson, S.R. Earnshaw, R. Farkouh, L. Schwamm
Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective
American Journal of Neuroradiology Oct 2010, 31 (9) 1669-1674; DOI: 10.3174/ajnr.A2138

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Cost-Effectiveness of CT Perfusion for Selecting Patients for Intravenous Thrombolysis: A US Hospital Perspective
D. Jackson, S.R. Earnshaw, R. Farkouh, L. Schwamm
American Journal of Neuroradiology Oct 2010, 31 (9) 1669-1674; DOI: 10.3174/ajnr.A2138
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  • Optimal Computed Tomographic Perfusion Scan Duration for Assessment of Acute Stroke Lesion Volumes
  • Different Imaging Strategies in Patients With Possible Basilar Artery Occlusion: Cost-Effectiveness Analysis
  • Drivers of Costs Associated With Reperfusion Therapy in Acute Stroke: The Interventional Management of Stroke III Trial
  • Systematic Review, Critical Appraisal, and Analysis of the Quality of Economic Evaluations in Stroke Imaging
  • Pre-intervention cerebral blood volume predicts outcomes in patients undergoing endovascular therapy for acute ischemic stroke
  • Acute Stroke Imaging: CT with CT Angiography and CT Perfusion before Management Decisions
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